Imisipha yakho iyakushiya njengoba ukhula! Uma ungawakhi umsipha, uzoba namathuba amaningi okuthola isisindo kunabanye, futhi ukuhlala isikhathi eside kuzodala "umbuthano wokubhukuda." Abantu asebekhulile ngeminyaka, njengabazali nogogo nomkhulu, bavame ukuba nomuzwa wokuthi izitho zomzimba zabo zibuthakathaka futhi bakuthola kunzima ukukhuphuka izitebhisi, okubangelwa nokuncipha kwe-calcium ngenxa yokukhula, okubangela izinkinga zamathambo. Kwatholakala ukuthi i-HMBCa ingazixazulula lezi zinkinga. Esixukuni sokufaneleka, singahlinzeka ngesengezo sokudla okunempilo kwemisipha. Kubantu abaneminyaka ephakathi kanye nasebekhulile bangasiza ekuvimbeleni i-osteoporosis, ukubola kwemisipha; I-HMBCa yaziwa nangokuthi "umenzi wemisipha".

Ngaphezu kwalokho, izifundo zezokwelapha zithole ukuthi i-HMBCa ingasiza futhi abantu abanezimila ukubuyisela impilo yemisipha.

Ucwaningo luye lwabonisa ukuthi ukwengezwa 3 amagremu ngosukui-calcium beta-hydroxy-beta-methylbutyrate (HMB), i-metabolite engokwemvelo ye-amino acid leucine ebalulekile yomzimba, ingavimbela noma ihlehlise ukulahleka kwemisipha yamathambo. Umzimba womuntu ungakhiqiza ngokwemvelo, ungabuye utholakale emvelweni (njengenyama yenkomo, amaqanda, i-broccoli, njll.), kodwa kuwumkhondo, ukuze kugcinwe impilo yemisipha yeziguli ezinomdlavuza, noma kufanele kungezwe yi-HMB exogenous.

Yini i-HMBCa

I-HMB itholakala kakhulu ezithelweni ezisawolintshi, imifino ethile efana ne-broccoli, imidumba efana ne-alfalfa, nezinhlanzi ezithile kanye nezilwane zasolwandle. Ekukhiqizeni izimboni, ukuze kube lula ukugcinwa nokusetshenziswa, i-HMB ivame ukuguqulwa ibe usawoti we-calcium ngesikhathi sokuhlanganiswa, evame ukusetshenziswa ku-monohydrate, okuyi-β-hydroxy-β-methylbutyrate calcium monohydrate.

I-HMB iyi-metabolite esebenzayo yochungechunge lwegatsha olubalulekile lwe-amino acid leucine, engakhuthaza ukwakheka kwamaprotheni futhi inciphise ukuwohloka kwayo, ngaleyo ndlela yandise amandla omzimba womuntu, ibambezele ukukhathala kwemisipha, futhi iphinde isize ukuvimbela ukuwohloka kwemisipha kubantu asebekhulile.

Kusukela ngo-2011, ukudla okusha kwe-HMB? bekukhathazeke kakhulu ngamabhizinisi okudla asekhaya. Ngo-2017, Ikhomishana Kazwelonke Yezempilo Nokuhlela Umndeni yamemezela ukunwetshwa kobubanzi bokufaka isicelo be-HMB? ukusuka ezinhlelweni ezimbili zokuqala ukuya kweziyisishiyagalolunye.

Uhlelo lokusebenza lwe-HMBCa

1. Indlela yokusebenza nokuphepha kwe-HMBCa

I-Beta-hydroxy-beta-methylbutyric acid (HMB) iyi-metabolite ye-leucine. Ama-amino acid e-branched chain akha amaprotheni angaphezu kwama-30% emisipha, phakathi kwawo i-leucine okuwukuphela kwe-amino acid engalawula ukuguqulwa kwamaprotheni emisipha yohlaka lwamathambo nenhliziyo, engalawula ukwakheka kwemisipha, ivimbele ukuwohloka kwamaprotheni kanye nokululama kokulimala kwezemidlalo.

I-HMBCa ingenye yezindlela ezivamile ezihambisanayo ze-HMB, futhi iyinsiza entsha yezinto ezingavuthiwe ezigunyazwe uMnyango Wezempilo e-China, futhi ukuphepha kwayo kuhlolisiswe kabanzi. Ezifundweni zabantu, ukuthathwa kwansuku zonke kwe-6gHMB akutholakalanga ukuthi kunomphumela ku-cholesterol, i-hemoglobin, amangqamuzana amhlophe egazi, amazinga kashukela egazini, isibindi nokusebenza kwezinso ngemva kwenyanga engu-1 yokusetshenziswa. U-Baier wafunda ukusetshenziswa kwansuku zonke kwe-2 kuya ku-3gCaHMB ngengxube ye-amino acid kubantu asebekhulile, futhi akukho zinguquko ezitholakele egazini lesibindi nezinso negazi legazi ngemuva konyaka ongu-1 wokusetshenziswa.

2. Ukusetshenziswa kwe-HMBCa ekudleni kwezilwane

Ucwaningo luye lwabonisa ukuthi ukusetshenziswa kwe-HMBCa ezinkukhu zenyama kungathuthukisa ukusebenza kokukhula futhi kwandise okuqukethwe kwenyama engenamafutha, ukuze kwandiswe ngempumelelo isivuno senyama, kanye nokwengezwa kwe-HMBCa okuphakelayo kungathuthukisa ukukhula kwemfuyo nezinkukhu futhi kuthuthukise ukuzivikela kwezilwane.

UGuo Junqing et al. ukhethe izimbuzi zoboya obumhlophe be-Inner Mongolia ezinempilo futhi wengeza ukugxila okuhlukile kwe-HMBCa kanye ne-leucine ekudleni okuyisisekelo. Imiphumela yabonisa ukuthi ukungezwa kwe-leucine ne-HMBCa ekudleni kungakhuphula okuqukethwe kwe-serum lysozyme, kwandise okuqukethwe kwe-serum immunoglobulin futhi kuthuthukise ukusebenza komzimba wokuzivikela komzimba.

3. Ukusetshenziswa kwe-HMBCa kwezokudla kwezemidlalo

Ucwaningo luye lwabonisa ukuthi ukudla i-calcium beta-hydroxy-beta-butyrate ngemva kokuzivocavoca akukwazi nje ukusheshisa ukulungiswa kwezicubu zemisipha, kodwa futhi kukhuthaze ukukhula kwevolumu yemisipha, ukwandisa ukukhuthazela, nokuthuthukisa amandla.

Ngo-Okthoba 2013, i-International Society of Sports Nutrition (ISSN) yenze ukuhlaziya okuqinile nokunemininingwane yezincwadi ze-HMB njengesengezo sokudla okunempilo futhi yenza isitatimende esilandelayo. ① Ngokulimala kohlaka lwamathambo okuvivinya umzimba kubantu abaqeqeshiwe nabangaqeqeshiwe, i-HMB inganciphisa ukulimala kwemisipha futhi ikhuthaze ukululama. Abasubathi bazohlomula ekuziqeqesheni nasekufakeni izintambo nge-HMB. ③ Faka i-HMB ngaphambi kokuzivocavoca amaviki angu-2 ukuze uthole imiphumela ehamba phambili. Ukuzivocavoca okufanele kubantu abaqeqeshiwe noma abangaqeqeshiwe, okuhambisana nesengezo sansuku zonke se-38mg/kg·BMI ye-HMB, kungakhuthaza ukukhula kwemisipha yamathambo futhi kwandise amandla emisipha namandla. Imiphumela ye-HMB ihlanganisa ukuwohloka kwamaprotheni okuncishisiwe kanye nokukhula kwamaprotheni.

4. Ukusetshenziswa kwe-HMBca ekudleni kwefomula ngezinjongo ezikhethekile zezokwelapha

Ukudla okwenziwa ngefomula ngezinjongo zokwelapha ezikhethekile kunokubaluleka okubalulekile emtholampilo ekulungiseni ukungalingani kwezinqubo ze-metabolic, ukunciphisa izinkinga ezinjengokutheleleka, ukuthuthukisa umphumela wezindlela ezihlukahlukene zokwelapha, ukukhuthaza ukululama, ngaleyo ndlela kufinyeze ukuhlala esibhedlela nokuthuthukisa izinga lempilo yeziguli.