1.1 Ukusuka ekulungisweni kolwelwesi lwamaseli kuya kumthethonqubo we-Cerebrovascular

Njengoba i-Citicoline yaqala ukuhlanganiswa yi-Takeda Pharmaceutical yase-Japan ngo-1956, umlando wokusetshenziswa kwayo ungathathwa njengomlando wokuthuthukiswa kwengqondo:

• 1980s:Isetshenziswa kuphela njenge-ejenti yokulungisa ulwelwesi lwamaseli ngemva kokushaywa unhlangothi

• 2010s:Kutholwe ukuthi kungakhuphula ukugcwala kwegazi kwe-cerebral (i-PET-CT ibonise ukwanda okungama-23% kokugeleza kwegazi le-lobe yesikhashana)

• Ngo-2024,I-NIH yase-United States ifake ohlwini njengento ebalulekile yokulawula "i-neurovascular coupling"

1.2 Ukukhula ngesivinini kwezimakethe zomhlaba

Ngokusho kwedatha ye-Evaluate Pharma:

Ukuthengiswa komhlaba wonke kufinyelele kumadola ayizigidi eziyizinkulungwane ezingama-4.7 ngo-2024 (CAGR 12.3%)

Ukusetshenziswa kwezidakamizwa ezibhedlela ezingamasampula eChina kwenyuke ngo-400% eminyakeni emithathu

Izinkomba zinwetshiwe ukuze kuthi:

I-Vascular dementia (isikolo se-MMSE sithuthukiswe ngamaphuzu angu-2.1)

Ukulimala kobuchopho okubuhlungu (isilinganiso se-GOS sokubikezela sikhuphuke ngamamaki angu-1.5)

Isahluko Sesibili: Ukuqhekeka Kwebhokisi Elimnyama Lendlela Yesenzo

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2.1 Izindlela zezenzo ezintathu

Izinga lobufakazi bomphumela oqondiwe: I-Phosphatidylcholine synthesis ilungisa ubuqotho bolwelwesi lwe-neuronal Ikilasi I: Izandulela ze-Acetylcholine zithuthukisa ukudluliswa kwe-neurotransmitter Isigaba IIA: Ukulawulwa kwe-nitric oxide synthase kuthuthukisa ukunwebeka kwe-microvascular (ububanzi bukhuphuka ngo-18%) Ikilasi le-IIB

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2.2 Isikhathi sewindi legolide lasemtholampilo

Ucwaningo lwango-2024 olwenziwa yiFirst Affiliated Hospital of Sun Yat-sen University lukhombisa:

Umjovo we-intravenous we-1000mg phakathi namahora angu-6 ngemva kwe-cerebral infarction ungasindisa indawo ye-ischemic penumbra kuze kufike ku-7.2cm.3

Nokho, awubanga khona umehluko obalulekile ngokwezibalo lapho abaphathi bedlula amahora angama-72 (p=0.34).

Isahluko Sesithathu: I-Vortex of Controversy

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3.1 Ukungabaza mayelana nokuba semthethweni

I-UK NICE Guidelines: Kucatshangwa ukuthi ubufakazi obukhona abanele ukusekela ukuhlinzekwa komshwalense wezempilo (isilinganiso sezindleko ezisebenzayo ￡ 45,000/QALY)

I-Lancet Neurology **Ukuhlaziywa kwe-Meta ka-2025: Awukho umehluko obalulekile kusuka ku-placebo eqenjini lokukhubazeka kwengqondo okumaphakathi (p=0.21)

3.2 Izinxushunxushu Ekuthuthukisweni Kwezohwebo

Isaziso sika-2024 sikaNational Medical Products Administration:

Amabhizinisi ayishumi nambili enze ihaba izinkomba (ezikhuthaza "ukwelashwa kwe-adjuvant" njengokuthi "ukubuyisela ukuwohloka komqondo").

Ukuhlolwa kwenkundla ethile ye-e-commerce kubonisa ukuthi okuqukethwe kwangempela okungu-32% kwamalungiselelo omlomo kungaphansi kuka-70% yenani elilebuli.

Isahluko Sesine: Imingcele Yentuthuko Yezobuchwepheshe

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4.1 Uhlelo Olusha Lokulethwa Kwezidakamizwa

Isithiyo segazi nobuchopho obungena ku-peptide eshintshiwe ye-liposomes (I-Patent Yethimba Lenyuvesi yase-Peking, CN202410123456.7)

Ama-microneedles aphendulayo aqhubekayo (Ukuhlolwa kwezilwane e-Seoul National University e-South Korea kubonisa ukwanda okuphindwe kathathu kwe-bioavailability)

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4.2 Ukuqala Komuthi Oyedwa Ngamunye

Ucwaningo oluhlangene lwe-Bgi luthole ukuthi:

Umphumela womuthi we-CDP-cholinesterase gene polymorphic population (ibalwa ku-31% wabantu base-Asia) unyuke ngo-47%.

Isahluko Sesihlanu Idatha Yomhlaba Wangempela Yeziguli

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5.1 Amacala Abahlomulayo

Irekhodi elivela esibhedlela semfundo ephakeme e-Hangzhou: Ngemuva kokwelashwa okuhlangene, umthamo wokugcinwa kwegazi lobuchopho wesiguli esineminyaka engu-62 esinobuchopho infarction ululame ukusuka ku-32% ukuya ku-89%.

5.2 Ukuzisho ngokwakho kweqembu elingavumelekile

"Ukuyithatha isigamu sonyaka ngokuqhubekayo, izindleko zenyanga zamayuan angama-300 zaletha ukungaphatheki kahle kwesisu" - irekhodi lenhlolokhono kaNks Li, isiguli saseBeijing.