Bangaphezu kwezigidi ezingama-500 abantu emhlabeni wonke abanesifo sikashukela, u-90% wabo abanesifo sikashukela sohlobo 2. Iziguli zidinga ukulawula ukuguquguquka kukashukela wegazi impilo yonke, futhi ushukela wendabuko (ofana ne-sucrose ne-fructose) ubhalwe njenge-contraindication yokudla ngoba udala ukuthi ushukela wegazi ukhuphuke. Nokho, kunzima ukuqeda isidingo somzimba womuntu sokunambitha ubumnandi, futhi kwaba khona imikhiqizo ethatha indawo kashukela. I-Sucralose, njenge-sweetener yesizukulwane sesine, idonse ukunaka okubanzi ngezakhiwo zayo "ezingama-calorie aziro nobumnandi obuphezulu" 13.

2. Izici ze-metabolic nokuphepha kwe-sucralose
1. Inzuzo ye-Metabolic
Isakhiwo samangqamuzana e-sucralose siguqulwa yi-chlorination, engaboliswa ngama-enzyme okugaya abantu. Cishe i-85% ye-sucralose ikhishwa ngqo emathunjini ngemva kokuyiphuza, kanti i-15% esele igaywa isibindi ibe yizinhlanganisela ezingenabo ubuthi futhi ikhishwe emchamweni. Ucwaningo lwezokwelapha luqinisekisile ukuthi inkomba yayo ye-glycemic ingu-0, futhi akukho ukuhlobana okuqondile nokukhiqizwa kwe-insulin 12. Isibonelo, ucwaningo olulawulwa ngo-2024 yi-International Diabetes Federation (IDF) aluzange lubonise izinguquko ezibalulekile ekuzileni kweglucose yegazi kanye namazinga e-A1C ezigulini ezingama-50 ezinesifo sikashukela sohlobo 2 eziphuze iziphuzo ze-sucralose izinsuku ezingama-30 zilandelana 5.

2. Ukuhlaziywa kwe-dialectical kwezingxabano zokuphepha
Nakuba ucwaningo olujwayelekile lusekela ukuphepha kwalo, kusenokukhathazeka ngezingozi ezingaba khona:

Umthelela we-gut microbiota : Ucwaningo lwango-2024 olwanyatheliswa kuyi-Nature Microbiology lubonise ukuthi ukudla kwansuku zonke okungaphezu kuka-15g we-sucralose kuvimbela umsebenzi wama-probiotics njenge-bifidobacterium, okubangele ukwehla okungama-20% -30% ezinhlobonhlobo ze-gut microbiota 37;
Ukusebenzisana kwezidakamizwa : Uma ihlanganiswa ne-anticoagulant warfarin, i-sucralose inganciphisa ukutholakala kwezidakamizwa ngo-12% -15%. 27 kufanele ithathwe amahora ama-2 ngokuhlukana;
.
ukucubungula ubungozi bomkhiqizo ophuma kumkhiqizo : ukubhaka okuphezulu kwezinga lokushisa (> 150℃) kungase kukhiqize amanani amancane e-chloropropanol (Okwesithathu, isu lesayensi lokushintsha ushukela
1. Ukulawulwa komthamo kushintshwa ukuze kufane nendawo yesigameko
I-World Health Organization (WHO) incoma ukuthi abantu abanesifo sikashukela bangadli ngaphezu kwe-9mg/kg ye-sucralose ngosuku (cishe ama-540mg kumuntu omdala ongu-60kg). Izimo zidinga ukuhlukaniswa ezinhlelweni ezisebenzayo:

isiphuzo isinongo ?: 300ml isiphuzo sokudla siqukethe cishe 30mg sucralose, okuyi-5.5% kuphela yomkhawulo ophephile 16;
Izinto ezibhakiwe ? : Khetha ikhekhe elenziwe ngenqubo yezinga lokushisa eliphansi (2. Ukulawulwa kokudla okudidiyelwe
Okuthatha indawo kashukela akuthathi indawo yokulawula ushukela jikelele:

umsoco olinganiselayo : Hlanganisa okusanhlamvu okuphelele (i-GI engaphansi kuka-55) kanye ne-fiber yokudla (25-30g nsuku zonke) ukuze ubambezele ukumuncwa kwe-glucose 46;
Ukuqapha ushukela wegazi : I-glucose esegazini itholwe emahoreni ama-2 ngemuva kokudla ukudla okuthatha indawo kashukela, futhi kwasungulwa ingobo yomlando yokuphendula yomuntu ngamunye 58.
4. Izinkambiso zemboni kanye nemfundo yabathengi
1. Ukumiswa kokulebula kokudla
Inguqulo ebuyekeziwe Yemithetho Ejwayelekile YaseShayina Yokulebula Okunomsoco Kokudla Okupakishwe Kakhulu ngo-2025 idinga ukuthi ukudla okuqukethe i-sucralose kufanele kumakwe ngesixwayiso "Iziguli ezinesifo sikashukela zidinga ukulawula inani eliphelele lama-carbohydrate" futhi zibonise okuqukethwe okungeziwe (mg/100g) 24.

2. Ukusabela kwezinxushunxushu zemakethe
Ngo-2024, i-General Administration of Market Supervision yathola ukuthi u-18.7% "ongenashukela" ugcina ushukela owengeziwe, obukeka njenge-sucralose. Abathengi kufanele bakhethe imikhiqizo enesitifiketi se-SC kanye nemibiko yokuhlola ephelele engu-78.

5. Isiqondiso Sokuthuthukiswa Kwekusasa
1. Ukuqamba okusha kwezobuchwepheshe
Ngo-2025, iJinhe Industrial yethula inqubo "ye-chlorination eqondisiwe" yokunciphisa inani elisele le-sucralose chloropropanol ibe ngu-0.01ppm, futhi yandisa isikhathi sokukhululwa kwamathumbu ngobuchwepheshe be-microcapsule ukunciphisa ukuphazamiseka kwamagciwane 18.

2. Ucwaningo lwezokwelapha olusekelwe ebufakazini
I-International Diabetes Association yethule uhlelo lokulandela lweminyaka engu-5 "lokushintshwa ushukela kanye ne-metabolic syndrome" ukuhlola ukuphepha kwesikhathi eside kwe-sucralose kubantu abayi-100,000 abanesifo sikashukela.