Ngo-1832, usokhemisi ongumFulentshi uMichel Eug è ne Chevreul waqala ukuthola i-creatine emisipha yamathambo, kamuva eyaqanjwa ngokuthi "Creatine" egameni lesiGreki elithi "Kreas" (inyama). I-Creatine igcinwa ikakhulukazi esicupheni semisipha, esinganciphisa ukukhathala nokuqina kwemisipha, ithuthukise ukunwebeka kwemisipha, yenze imisipha ibe namandla, isheshise ukwakheka kwamaprotheni emzimbeni womuntu, inciphise i-cholesterol, i-lipids yegazi, noshukela egazini, ibambezele ukuguga, futhi ibambe iqhaza lapho isidingo samandla siphezulu. Ngokufaka i-creatine, umzimba womuntu ungakhuphula i-creatine reserves, uthuthukise amazinga e-phosphocreatine emisipha, futhi uthuthukise ukusebenza kokuzivocavoca kwesikhashana, okuphezulu kakhulu. Ucwaningo luye lwabonisa ukuthi izithako ze-creatine azikwazi nje ukubambezela ukukhathala kwemisipha, zithuthukise amandla okuqhuma nokukhuthazela kwabasubathi, kodwa futhi zisize ukukhuthaza ukukhula kwemisipha nokululama, okwenza kube isithasiselo esisebenzayo sokudla okunempilo kwabathandi bokuqina kanye nabasubathi.