1. Indlela eyinhloko

I-Glyoxylate ye-bacterial metabolite ehlosiwe

Amagciwane amelana nezidakamizwa alawula ukuvezwa kwe-glyoxylate ezindaweni ezintula izakhi, alungisa kabusha izici ze-epigenetic, enze buthaka ukuphendula kwamasosha omzimba, futhi asize amagciwane aphile ngaphansi kwengcindezi yemithi elwa namagciwane ngokuvimbela umsebenzi we-DNA demethylase (TET2) kumaseli aphethe.

I-Vitamin C ivuselela umsebenzi we-enzyme ye-TET2

I-Vitamin C, njengesishoshovu semvelo se-TET2, ingamelana nomphumela ovimbelayo we-glyoxylate kumasosha omzimba abamba iqhaza, ibuyisele ukusebenza kwe-DNA demethylation, futhi iqale kabusha amasosha omzimba.

Ukuphazamisa isu "lokufa kwamanga" kwamagciwane

I-Acetaldehyde ngasikhathi sinye yenza kusebenze indlela yokuzivikela yamagciwane, yakhe abaphikelelayo ukuze bagweme ukubulawa kwama-antibiotic. I-Vitamin C ehlanganiswe nemithi elwa namagciwane inganqamula lokhu kujwayela kwe-metabolic futhi yehlise kakhulu umthwalo wamagciwane.

2. Ubufakazi bokuhlola

Ukuqinisekiswa kwemodeli yezilwane: Kumodeli yokutheleleka kwegundane, inhlanganisela kavithamini C kanye nama-antibiotics yenyusa izinga lokusinda ngo-60%, yehlisa umthamo wamagciwane ezicutshini ngo-80%, futhi yehla amazinga ezinto ezivuthayo ngo-50%.

Umphumela we-Synergistic: I-Vitamin C ithuthukisa indlela yokubonisa i-interferon (IFN), iqinisa ikhono le-immune cell ukusula amagciwane amelana nezidakamizwa, futhi ivimbela i-STAT1 dephosphorylation, yandisa isikhathi sokuphendula kwamasosha omzimba e-anti-tumor.

3, Amandla okusebenza emtholampilo

Ukunqoba inkinga yokungazweli emuthini: Leli su lihlinzeka ngokwelashwa okusha okungancikile kuma-antibiotic ezifweni zebhaktheriya ezimelana nomuthi njenge-Salmonella ne-Mycobacterium tuberculosis, ikakhulukazi ezigulini ezinezifo eziphindelelayo noma ama-antibiotic angasebenzi.

Uhlelo lokwelapha olwenziwe lula: I-Vitamin C, njengesakhamzimba esiphephile futhi esinezindleko eziphansi, ingasetshenziswa ngokuhambisana nama-antibiotic akhona ukuze kwehliswe umthamo wezidakamizwa futhi kuncishiswe imiphumela emibi.

Inani lokwengeza elivimbelayo: Ukudla okwanele kwama-micronutrients (njengovithamini C) kungase kunciphise ngokungaqondile ingozi yokudluliselwa kofuzo olumelana nomuthi ngokugcina ibhalansi ye-gut microbiota.

4. Izikhombisi-ndlela zocwaningo lwesikhathi esizayo

Hlola imiphumela ye-synergistic kanye nezinhlanganisela zomthamo ezilungile zikavithamini C namanye ama-antibiotic afana ne-beta lactam nama-quinolones.

Linganisa umthelela wokwengezwa kukavithamini C wesikhathi eside ekuguqukeni kwezibalo zamabhaktheriya amelana nemithi.

Ukuthuthukisa inoveli yemithi elwa namagciwane eqondise ku-glyoxylic acid-TET2 axis