I-Lycopene (LYC), i-carotenoid, i-pigment encibilikayo ngamafutha, etholakala kakhulu kutamatisi, ikhabe, i-grapefruit nezinye izithelo, i-pigment eyinhloko kutamatisi ovuthiwe. I-Lycopene inezinhlobonhlobo zezinzuzo zezempilo, okuhlanganisa ukukhipha ama-radicals mahhala, ukunciphisa ukuvuvukala, ukulawula i-glucose ne-lipid metabolism, nemiphumela ye-neuroprotective.

Muva nje, Abacwaningi abavela e-Shanxi Medical University bashicilele iphepha kumagazini i-Redox Biology enesihloko esithi "Lycopene inciphisa ukushoda kwengqondo okuhlobene nobudala ngokusebenzisa i-activate yesibindi-ubuchopho. Iphepha lokucwaninga le-fibroblast growth factor-21 signaling ".

Ucwaningo luye lwabonisa ukuthi ukugcwalisa nge-lycopene izinyanga ze-3 kungabambezela ukuguga kobuchopho kumagundane futhi kunciphise ukulimala kwengqondo okuhlobene neminyaka, futhi i-lycopene ithuthukisa ukuwohloka kwe-neuronal, ukungasebenzi kahle kwe-mitochondrial, ukulimala kwe-synaptic, futhi ikhuthaze ukuhlanganiswa kwe-synaptic vesicle kumagundane aguga.

Ngaphezu kwalokho, i-lycopene isebenze i-axis yesibindi-yobuchopho i-FGF21 ebonisa amagundane asebekhulile, ngaleyo ndlela ikhuthaza ukukhululwa kwama-neurotransmitters ngokwandisa amazinga e-ATP e-mitochondrial kanye nokuthuthukisa i-synaptic vesicular fusion. Lokhu kuphakamisa ukuthi i-FGF21 ingase ibe inhloso yokwelapha kumasu okungenelela okunomsoco ukuze kubambezeleke ukuguga kobuchopho nokuthuthukisa ukukhubazeka kwengqondo okuhlobene neminyaka.

Ekugugeni, ukuguga kobuchopho, ukungasebenzi kahle kwe-mitochondrial kungenye yezinto ezibaluleke kakhulu, abacwaningi bathola ukuthi i-lycopene supplementation ingathuthukisa ukulimala kwe-mitochondrial morphological, futhi ihlehlise izinga le-mitochondrial electron yokuthutha eyinkimbinkimbi ebangelwa ukuguga, ukukhuthaza ukukhiqizwa kwe-ATP, okubonisa ukuthi umsebenzi we-lycopene unomphumela wokuvikela emitoni.

Ekugcineni, abacwaningi baphinde benza izivivinyo ze-in vitro futhi bathola ukuthi i-lycopene ithuthukise ikhono lamaseli esibindi ukusekela ama-neurons, okuhlanganisa ukuthuthukisa ukuguga kwamaseli, ukuthuthukisa umsebenzi we-mitochondrial, nokwandisa ubude be-axon ye-neuron.

Uma ihlanganiswa, imiphumela iphakamisa ukuthi ukwesekwa kwe-lycopene kungabambezela ukuguga kobuchopho futhi kuvimbele ukukhubazeka kwengqondo okuhlobene neminyaka kumagundane, ngokwengxenye ngoba i-lycopene ivuselela ukusayinda kwe-hepato-brain axis FGF21, ephakamisa ukuthi i-FGF21 ingase ibe inhloso yokwelapha ekungeneleleni okunomsoco ukuze kuthuthukiswe izifo ezibangelwa yi-neurogenerative cognitive.