(1) Izakhi zokuphila ezenzeka ngokwemvelo

Njenge-monosaccharate yemvelo, i-mannose yatholakala ku-epidermis yama-apula (0.7-1.2%) namawolintshi (0.3-0.8%). Ifomula yayo yamangqamuzana ibingu-?. C?H??O? kanye neglucose ?. 8. Ngesikhathi se-metabolism yomuntu, i-mannose ingena kumaseli ngesithuthi esithile, i-GLUT1, kodwa ingaluvuli uhlelo lokukhiqiza i-insulin, okuyisici esenza kube ukukhetha okumnandi okuphephile kwabanesifo sikashukela 48.

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(2) Ukwanda kwezithasiselo zokudla ezintsha

Ngo-2023, Ikhomishana Yezempilo Kazwelonke yabhala i-konjac mannose oligomeric njengokudla okusha okungaphekiwe, okumaka ukungena ngokusemthethweni kwe-mannose emkhakheni wokufaka isicelo embonini yokudla .7. Izinga le-polymerization ye-mannose oligosaccharide etholwe nge-enzymatic hydrolysis ye-konjac glucomannan ilawulwa ngaphakathi kwamayunithi kashukela angu-2-10, angagcini nje kuphela izici zemvelo kodwa futhi ekwazi ukuzivumelanisa nezimo. I-7 isetshenziswe ezinhlotsheni zokudla ezingaphezu kuka-20 njengeziphuzo ezingenashukela namabhisikidi asebenzayo.

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Okwesibili, indlela enempilo yokunika amandla i-mannose

(a) umgoqo wemvelo wohlelo lomgudu womchamo

Idatha yomtholampilo ibonisa ukuthi i-2g ye-mannose ngosuku inganciphisa izehlakalo zokutheleleka okuphindaphindiwe komgudu womchamo kwabesifazane ngama-38% 8. Indlela yokusebenza kwayo ihlanganisa:

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imvume yomzimba : Amaphesenti angama-90 okudla akhishwa nge-urethra phakathi nemizuzu engu-30-60, futhi amagciwane e-pathogenic (afana ne-E. coli) akhishwa emzimbeni 8;

i-biofilm cracking ? : bhubhisa i-β-1, 4-glucoside bond yebhaktheriya biofilm, thuthukisa ukusebenza kahle kokubulala amagciwane izikhathi ezi-3 78;

i-immune regulation : ukukhuthaza ukugcinwa kwe-defensin ngamaseli e-urethral epithelial, kuthuthukise ukuzivikela kwendawo 8.

(2) Umqaphi ongabonakali wempilo yamathumbu

I-Konjac mannooligosaccharide ingandisa ama-probiotics afana ne-bifidobacterium, futhi ikhulise ukuchichima kwezitshalo zamathumbu ngo-25% 7. Esivivinyweni somtholampilo e-Wuhan Union Medical College Hospital, ngemva kokuthatha i-mannose oligosigro amasonto ama-4, imvamisa yokuphuma amathumbu inyuke isuka ku-2.3 yaya ezikhathini ezi-4.1 ngesonto, futhi izigameko zokuvuvukala kwesisu zehle ngo-62% 7.

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(3) Ithuluzi lokuvimbela nokulawula izifo ze-metabolic

Ngokungafani nama-sweeteners okwenziwa, imannose inenkomba ye-glycemic (GI) engu-0, futhi ukufaka esikhundleni se-sucrose ezimpahleni ezibhakiwe kwehlisa izinga likashukela wegazi wangemva kokudla ngo-2.1mmol/L ezigulini ezinesifo sikashukela esingu-78. Ucwaningo lwe-2024 Journal of Nutrition luqinisekisile ukuthi i-mannose ithuthukisa ukubekezelela ushukela ezigulini ezimelana ne-insulin ?7 ngokuvula indlela ye-AMPK.

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3.Izinqubo ezintsha embonini yokudla

(1) Izibonelo zokuthuthukiswa kokudla okusebenzayo

iziphuzo ezivikela umchamo : 500mg/ ibhodlela le-mannose oligosaccharide lafakwa esiphuzweni esiyinkimbinkimbi se-cranberry sohlobo oluthile, futhi umthamo wokuthengisa wedlula amacala ayizigidi ezi-2 engxenyeni yokuqala yonyaka wesi-7;

Ibhikawozi elawula ushukela : isinkwa esibuyisela ukudla esenziwe nge-konjac ne-mannose-oligosaccharide sine-carbohydrate engaphansi ngo-45% kanye ne-fiber ephindwe kathathu 7;

Ukuqinisa ukudla okunomsoco wezingane : Izinti zikashizi ezinemannose engeziwe zingakhuthaza izinga lokumunca i-calcium ngo-18%, elifakwe ohlelweni lokuphakelwa kwezingane ezingu-30% 7.

(2) Impumelelo ekucubunguleni ukuqanjwa kabusha kobuchwepheshe

Ubuchwepheshe obuqondisiwe be-enzymatic hydrolysis obuthuthukiswe amabhizinisi e-Hubei bukhuphule izinga lokuguqulwa kwe-konjac glucomannan lisuka ku-58% laya ku-92%, futhi lwehlisa izindleko zokukhiqiza ngo-40% 7. Ukusetshenziswa kwenqubo ye-microencapsulation kunwebise ukuzinza kwe-mannose kwamaminithi angu-60 ku-120 ℃, futhi kwanweba ukusetshenziswa kwayo emkhakheni wokubhaka 48.

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4.Ingqondo yesayensi kanye nokusetshenziswa okunengqondo

(1) Umthetho Wegolide wokulawula umthamo

Umkhawulo wokuphepha : ukudla okukodwa akudluli ku-3g, ukudla kwansuku zonke kulawulwa ngaphakathi kwe-5g, ngokweqile kungase kubangele ukuphazamiseka kwesisu, isifo sohudo (isigameko esibalelwa ku-7%) 8;

Isexwayiso esikhethekile sesibalo sabantu : iziguli ezingakwazi ukusebenza kahle kwezinso izinga lokuphuma kwegazi lehle ngo-50%, zidinga ukusebenzisa u-8 ngaphansi kokuqondisa kukadokotela;

I-Synergistic scheme : Ihlanganiswe ne-cranberry extract, umphumela we-antibacterial ukhuphuke izikhathi ezingu-2.3 izikhathi ezingu-8.

(2) Ukuthuthuka kwemboni kwamazinga okumaka

Imithetho Ejwayelekile Yokulebula Okunomsoco Kokudla Okupakishwe Ngaphambilini njengoba ichitshiyelwe ngo-2024 idinga:

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Imannose iyomakwa ngokwehlukana ohlwini lwezithako futhi akufanele ihlanganiswe negama elijwayelekile elithi "sweetener" 7;

Izimangalo zomsebenzi zidinga ukumakwa "hhayi ezokwelashwa okuhlukile kwezidakamizwa" 8;

Umthamo ≥1g/100g kufanele umakwe ukuthi "kungabangela ukungakhululeki okuncane kwamathumbu" 7.

1.Izingxabano namathemba esikhathi esizayo

(1) Ukugxila okukhona kwengxabano

Imiphumela yesikhathi eside okufanele ibhekwe : imiphumela yesikhathi eside yokudla okuqhubekayo iminyaka engaphezu kwengu-5 ezimila emathunjini ayicacile 7;

Imvelo : Ukuthi inqubo ye-enzymatic hydrolysis ishintsha izici ezibalulekile zezinto kubangela ingxoxo yezemfundo 7;

Imithelela yochungechunge lwezemvelo : Ukunwetshwa kokulima kwe-Konjac kuholele ekuguqulweni kuka-30% womhlaba wezitshalo zendabuko, okungase kuphazamise ukuhlukahluka kwemvelo 7.

(2) Isiqondiso sokuthuthukiswa kobuchwepheshe

ukusetshenziswa okunembayo : Ukuthuthukiswa kokuphuma kwe-mannose okuqondene nezinhlobo ezahlukene 8;

ukukhiqizwa okuluhlaza ? : Izinhlobo ze-Konjac ezithuthukisiwe ngobuchwepheshe be-CRISPR, okuqukethwe kwe-glucomannan kukhuphuke kusuka ku-60% kuya ku-85% 7;

Ukuqapha Okukhaliphile : Idivayisi egqokekayo iqapha ukugcwala kwe-urinary mannose ngesikhathi sangempela ukuze kusetshenziswe umuntu uqobo 8.

Isiphetho

Njengesibonelo sokuhlanganiswa kwemvelo nobuchwepheshe, i-mannose ayiqhubeki nje ukuhlakanipha kwasendulo ngaphansi kwesihlahla se-apula, kodwa futhi ikhanyisa ukukhanya kobunjiniyela bokudla besimanje. Ngaphansi kokuqondisa kwesu le-Healthy China 2030, lesi sengezo esisebenzayo nesiphephile sibumba kabusha imingcele yokuqonda kwabantu izithasiselo zokudla. Kodwa-ke, kuyadingeka ukuqaphela ukuthi ukusetshenziswa okunengqondo kwanoma yisiphi isithasiselo kufanele kusekelwe ekudleni okulinganiselayo, njengoba "Izithasiselo Zokudla Ezingenakugwenywa" zithi: "Isayensi nobuchwepheshe buye benza ukudla kube nokwenzeka, kodwa ukuhlonipha imvelo bekulokhu kuyisisekelo semboni yokudla.