Ubumnandi be-neotame bufana nobe-aspartame, ngaphandle kokubaba noma okunye ukunambitha. Ubumnandi be-neotame buphindwe izikhathi ezingu-8000-10000 kobe-sucrose, obuphindwe izikhathi ezingu-8000 kobesucrose ngo-5% ubumnandi futhi bufika izikhathi ezingu-10000 kobesucrose ngo-2%. Ngokusho kwe-GB2760-2011 Hygienic Standards for Food Additives, ehlinzekwe ngu-Zhang Le'an Ububanzi bokusetshenziswa kwe-Newsweet yizinhlobo ezahlukene zokudla neziphuzo, futhi inani lokusetshenziswa lifanelekile ngokwezidingo zokukhiqiza. Ngokuvamile, iziphuzo zine-concentration ye-8-17mg/L, kuyilapho imikhiqizo yokudla ine-concentration ye-10-35mg/kg.

Njengesishukela esisebenzayo, i-neotame ayinayo imiphumela emibi empilweni yomuntu futhi idlala indima enenzuzo yokulawula noma yokuthuthukisa. Kusukela ngo-December 1998, isicelo sokusetshenziswa kwezinga lokushisa eliphansi le-neotame njengesithako esimnandi sokudla safakwa e-United States. Yagunyazwa ukuthi isetshenziswe kukho konke ukudla neziphuzo yi-US FDA ngoJulayi 9, 2002. I-EU yasigunyaza ngokusemthethweni isicelo sayo ngoJanuwari 12, 2010.

Ubumnandi obuhlanzekile, obusha futhi bemvelo, obufana ne-aspartame, kodwa ngokuphepha okuphezulu;

Ubumnandi buphezulu, izikhathi ezingaba ngu-8000 ze-sucrose, futhi izindleko zobumnandi obulinganayo ziphansi kune-aspartame;

Izakhamzimba eziqukethwe zimuncwa kalula ngumzimba womuntu;

Amandla aphansi noma awekho amandla, atholakala kwabanesifo sikashukela, angewona ama-cariogenic, futhi angakhuthaza ukwanda kwe-bifidobacteria;

Ngeke kubangele ukubola kwamazinyo noma ukushintshashintsha kukashukela egazini, okulenza libe yi-sweetener ekhethwayo yokudla okunempilo.