I-Citicolineisetshenziswe kabanzi emisebenzini yomtholampilo, ikakhulukazi ekwelapheni i-neurological sequelae ebangelwa ukulimala kwe-craniocerebral noma ingozi ye-cerebrovascular, futhi ithole ukusetshenziswa okusha ekusebenzeni komtholampilo. Ukwelashwa kwayo ekopheni kobuchopho, isifo sikaParkinson, i-glaucoma, i-diabetic peripheral neuropathy kanye ne-tinnitus nezinye izifo nakho kudonse ukunaka okwandayo. Ngakho-ke yini i-citicoline, yimiphi imiphumela ye-pharmacological, izinkomba zayo (ukwelashwa okuqondile kwaziphi izifo), ukusebenza kahle nokuphepha?

I-Citicoline iyinucleotide eyodwa eyakhiwe i-ribose, i-cytosine, i-pyrophosphate ne-choline. Kuyi-nucleotide engapheli yomzimba womuntu. Ibandakanyeka ezindleleni eziningi ezibalulekile ze-metabolic emzimbeni. Kuyisandulela semvelo se-phospholipid synthesis yesakhiwo se-neuron cell membrane kanye nesandulela se-biosynthesis ye-neurotransmitter acetylcholine.

I-Citicoline iyi-ejenti ye-neuroprotective engavikela ama-neurons asengozini, ngaleyo ndlela yehlise noma ivimbele ukuqhubeka kwesifo. Njengamanje, ama-neuroprotective agents avame ukusetshenziswa emisebenzini yomtholampilo ahlanganisa izivimbela zesiteshi se-calcium, abaphikisana ne-glutamate, ama-scavengers ama-radical mahhala, nama-stabilizers olwelwesi lwamaseli, phakathi kwawo i-citicoline eyingxenye ye-stabilizer ye-cell membrane.

I-Citicolineinemiphumela eminingi yemithi eqondiwe, futhi lezi zindlela zesenzo ziyenza ibe namandla amakhulu ekuvimbeleni i-neuroprotection kanye nokulungisa izinzwa. Inomphumela we-neuroprotection wokuvimbela ukwenzeka kokulimala kwe-neuronal kanye nomthelela wokulungisa izinzwa ngemva kokuvela kokulimala kwe-neuronal, okunweba iwindi lesikhathi sokwelapha le-citicoline.

Ngokusekelwe ezintweni zayo zemithi, i-citicoline isetshenziswa kabanzi ekwelapheni isifo sohlangothi, ukukhubazeka kwengqondo, ukulimala kobuchopho okubuhlungu, isifo sika-Parkinson, i-glaucoma, i-diabetic peripheral neuropathy, i-tinnitus nezinye izifo, futhi ukusebenza kwayo nokuphepha kuye kwaqinisekiswa ezifundweni eziningi zemitholampilo, nobufakazi obanele bezokwelapha obusekelwe ebufakazini. I-Stroke: I-stroke iwuhlobo lokuvinjelwa noma ukuqhekeka kwemithambo yobuchopho, okuholela ekulimaleni kobuchopho besigaba sezifo, okuhlanganisa i-ischemic kanye ne-hemorrhagic stroke, okuwuhlobo oluyinhloko lokushaywa yi-ischemic, okubalelwa ku-75% kuya ku-90% yazo yonke imivimbo. Ingozi yempilo yonke yokushaywa unhlangothi emphakathini wethu ingu-35% -40.9%, ibalwa kuqala emhlabeni, hhayi lokho kuphela, isifo sohlangothi futhi siyimbangela yokuqala yokufa nokukhubazeka kubahlali bethu.

Ubufakazi bocwaningo lomtholampilo:

1. Ngo-2002, i-American Journal Stroke yashicilela i-meta-analysis yokuhlolwa komtholampilo ezigulini ezine-acute ischemic stroke, eyabonisa ukuthi i-oral citicoline yandisa amathuba okuba iziguli zohlangothi zilulame ngemva kwezinyanga ezi-3 [1].

2. Ngo-2009, ukuhlolwa kocwaningo lokuqapha izidakamizwa kwenziwa eNingizimu Korea ezigulini ezingu-4191 ezine-acute ischemic stroke, futhi imiphumela yabonisa ukuthi i-citicoline ithuthukise isikolo se-NIHSS kanye nenani le-BI leziguli ezinezinzuzo ekuqaleni kokwelashwa kwangaphambi kwesikhathi, kanye nezinzuzo zokusetshenziswa kwesikhathi eside zazinkulu, futhi umphumela wokwelapha wawuhlotshaniswa kahle nomthamo. Ukuthuthukiswa kwakubaluleke kakhulu eqenjini le-high-dose (≧2000mg / ngosuku), futhi ukusetshenziswa kwesikhathi eside kwakuphephile futhi kubekezelelwe [2].

3. Imiphumela yocwaningo lokuhlola olulawulwa yi-multicenter, olungahleliwe, oluyimpumputhe kabili, olulawulwa yi-placebo mayelana nokopha kobuchopho iphakamisa ukuthi i-citicoline iyisidakamizwa esiphephile sokwelapha ukopha kobuchopho ngomphumela omuhle wokwelapha [3].

4. Ucwaningo oluvulekile, olungahleliwe, oluhambisanayo luhlole umphumela we-citicoline ekukhubazekeni kwengqondo ngemva kokushaywa unhlangothi, futhi imiphumela yabonisa ukuthi ukusetshenziswa kwesikhathi eside kwe-citicoline kuthuthukisa kakhulu ukukhubazeka kwengqondo ngemva kokushaywa unhlangothi [4].