Ukuguga kuyinqubo eyinkimbinkimbi, enezigaba eziningi, kancane kancane eyenzeka kukho konke ukuphila. Ngokuhamba kwesikhathi, izitho nezicubu zomzimba womuntu zizoguga kancane kancane, kanti ezinye izifo zizovela ngokukhula kweminyaka, okuhlanganisa umdlavuza, isifo sikashukela, izifo zenhliziyo nokunye.

Ucwaningo olwengeziwe luye lwabonisa ukuthi amakhemikhali e-phytochemicals, okuhlanganisa ama-polyphenols, ama-flavonoid, ama-terpenoids, njll., angandisa impilo enempilo ngokusebenzisa i-anti-oxidation, ukusebenza kwe-autophagy ye-mitochondrial nezinye izindlela, futhi abe nezindawo zokulwa nokuguga.

Ngaphambilini, abacwaningi bathola ukuthi ukukhishwa kwe-sage kungabambezela ukuhlolwa kokuguga ku-vitro, futhi kumamodeli wegundane kanye ne-in vitro yabantu, ukukhishwa kwe-sage kunciphise kakhulu inani lamaseli e-beta-galactose sidase ahlobene nobudala, okubonisa izakhiwo zokulwa nokuguga.

Muva nje, Abacwaningi eNyuvesi yase-Padova e-Italy bashicilele iphepha kujenali ye-Nature Aging enesihloko esithi "Targeting senescence ebangelwa ubudala noma ukwelapha ngamakhemikhali nge-polyphenol-rich. i-extract yemvelo ithuthukisa impilo ende nempilo kumagundane."

Ucwaningo luye lwabonisa ukuthi ukukhishwa kwansuku zonke kwe-sage extract kungandisa isikhathi sokuphila nempilo enempilo yamagundane, kuvimbele ukuvuvukala okubangelwa ubudala, i-fibrosis kanye nezimpawu zokuguga ezinhlobonhlobo zezicubu, futhi kuthuthukise i-phenotypes yokuguga.

Kulolu cwaningo, abacwaningi bahlaziye amandla e-anti-aging of sage extract (HK) ku-vivo ngokusebenzisa amamodeli wegundane, ngokungeza imithamo ephansi ye-HK emanzini okuphuza nsuku zonke, futhi bahlaziya ukuqoqwa kwamaseli e-senescent kumamodeli wamagundane, kanye nemingcele eminingana ehlobene nobudala, kuhlanganise nokuphila isikhathi eside, impilo yomzimba, i-fibrosis, i-bone mineralization, nokuvuvukala.

Abacwaningi banikeze amagundane anezinyanga ezingu-20 amanzi okuphuza ane-HK aze ashona.

Imiphumela yabonisa ukuthi isilinganiso sokuphila kwamagundane eqenjini lokwelapha i-HK kwakuyizinyanga ezingu-32.25, kuyilapho isilinganiso sokuphila samagundane eqenjini elilawulayo sasiyizinyanga ezingu-28 kuphela. Ukwelashwa kwe-HK kwanweba isikhathi sokuphila ngezinyanga ezingu-4.25, futhi isikhathi sokuphila kwawo womabili amagundane esifazane nesilisa sanwetshwa kakhulu.

Ukuhlaziywa kwe-Histopathological kwesikhumba, isibindi, izinso, namaphaphu amagundane kwathola ukuthi ukwelashwa kwe-HK akuzange kubangele izinguquko kumingcele ye-hematopoietic noma ubuthi besitho, okubonisa ukuthi ukwelashwa kwe-HK kuphephile.

Ngaphezu kwalokho, ukwelashwa kwe-HK kuthuthukise ama-phenotypes okuguga kumagundane uma kuqhathaniswa nezilawuli, okuhlanganisa izici ze-hunchback, ukuthuthukiswa kwesimila, kanye nesimo soboya besilwane.

Le miphumela ikhombisa ukuthi ukwelashwa kwe-HK kungandisa impilo enempilo nempilo ende yamagundane, futhi akukho ubuthi obubonwayo.

Ukuhlaziywa okwengeziwe kwathola ukuthi ukwelashwa kwe-HK kwathuthukisa ama-phenotypes okuguga ezinhlobonhlobo zezicubu, okuhlanganisa ukulahleka kwezinwele okuthuthukisiwe, amathambo, impilo yemisipha, nokusebenza kwezinso.

Ukuhlaziywa kwe-Mechanism kubonise ukuthi ukwelashwa kwe-HK kwehlisa kakhulu isakhi sofuzo sokuguga isethi SAUL_SEN_MAYO, kuyilapho isethi yofuzo yokuguga elawulwa phezulu yayihlotshaniswa nokuvezwa ngokweqile kokuvuvukala, ukusebenza kokuzivikela komzimba, kanye nezindlela ezihlobene neminyaka, okuphakamisa ukuthi ukwelashwa kwe-HK kuguqule izici ze-transcriptome ezihambisana nokuvuvukala nokuguga. Ngaphezu kwalokho, ukuhlaziya imisipha, isikhumba, izinso, namaphaphu kwathola ukuthi ukwelashwa kwe-HK kunciphisa amazinga omaka bokuguga ezicutshini ezahlukene emzimbeni.

Ngaphezu kokuguga kwemvelo, abacwaningi baphinde bathola ukuthi ukwelashwa kwe-HK kungaphinde kuvimbele ukuguga kanye ne-cardiotoxicity ebangelwa i-chemotherapy drug doxorubicin, kuyilapho igcina umphumela wayo wokwelapha.

Ekugcineni, ngenxa yokuthi i-HK iyisiphuzo esiqukethe izinhlobonhlobo zezingxenye zezitshalo, abacwaningi bahlaziya izithako ezithile ezidlala indima yokuguga, futhi imiphumela yabonisa ukuthi ingxenye ye-flavonoid, i-luteolin (Lut), iyisithako esisebenzayo se-HK yokulwa nokuguga, okuthuthukisa ukuguga ngokushintsha ukusebenzisana phakathi kwe-p16 ne-CDK6.

Sekuhlanganiswe ndawonye, ??ucwaningo lwathola ukukhishwa kwemvelo okunemiphumela yokulwa nokuguga eyathuthukisa ukuguga kwamangqamuzana nezicubu, ukuthuthukisa izimpawu ezihlobene nobudala ezifana noboya, i-humpback, ukuqoqwa kwezimpawu zokuguga kanye nokulimala kwe-DNA ezicutshini, kanye nokuphila kwezilwane okwandisiwe.