I-SAIB(sucrose isobutyrate acetate) iyisisetshenziswa esisebenza ngezinto eziningi esebangeni lezemithi. Iwuketshezi lwe-viscous olulungiswe ngokulawulwa kwe-esterification kashukela wemvelo (sucrose) nge-acetic acid ne-isobutyric anhydride. Kuyingxube ekhiqizwa yi-distillation kanye nokukhiqizwa okuhlanzwe kakhulu. Ingasetshenziswa njengento eqhubekayo ye-ejenti yokukhululwa, i-solvent/carrier kanye ne-inhibitor yokusetshenziswa kabi kwezidakamizwa.

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Izici zomkhiqizo we-SAIB

I-SAIB iyi-solvent/carrier enhle kakhulu ye-hydrophobic API futhi inomsebenzi wokukhipha kancane.

I-SAIB ayicwebezeli futhi ihlala i-amorphous ekamelweni lokushisa, okukhuthaza kakhulu izinga eliqhubekayo lokulethwa kwezidakamizwa;

I-SAIB ayiyona i-polymeric futhi ayijiki noma izimvula lapho ihlangana noketshezi olunamanzi emzimbeni. I-SAIB iyancibilika kuzincibilikisi eziningi eziphilayo futhi iyahambisana nezinto eziningi; I-SAIB ingahlakazwa emanzini ngosizo lwezincibilikisi eziphilayo.

I-SAIB inezinto ezinamathelayo ze-bioadhesive futhi ingasetshenziselwa izinhlelo zokusebenza ze-transdermal, sublingual kanye ne-buccal patch.

Isicelo somkhiqizo

1. Libazisa ukukhululwa

Emfanekisweni ongenhla, kubonakala ukuthi i-SAIB inenani le-HLB cishe elingu-5, okubonisa ukuthi i-hydrophobic

2. Isixazululo se-API sokuncibilika kwamanzi okungesihle

IHydrophobic SAIB iyinyibilikisi/umthwali omuhle we-API onokuncibilika okuncane kwamanzi, futhi ukusetshenziswa kwe-SAIB kuthuthukisa ukunyibilika kwezidakamizwa ezingancibiliki ngokwentengiso.

3. Vimbela ukusetshenziswa kabi kwezidakamizwa

Ukusetshenziswa kwe-SAIB kwandisa usayizi wezinhlayiyana zama-opioid ngesikhathi sokugaya futhi kuphazamisa ukukhishwa kwezidakamizwa.

(1) Ama-polymers (i-polyoxyethylene kanye/noma i-hydroxypropyl methylcellulose) kanye ne-tocopherol acetate ama-granules enziwe ngesisombululo sotshwala se-SAIB. Amalungiselelo ahlukaniswa ngokuthi Angelaphekanga/Angelashiwe noma Elashiwe/Elashiwe(welashwe ngo-90oC imizuzu engama-30).

(2) I-Pseudoephedrine hydrochloride, ama-polymers (i-polyoxyethylene kanye/noma i-hydroxypropyl methylcellulose) kanye ne-tocopherol acetate ama-granules enziwe ngesisombululo sotshwala se-SAIB. Amalungiselelo ahlukaniswa ngokuthi Angelaphekanga/Angelashiwe noma Elashiwe/Elashiwe(welashwe ngo-90oC imizuzu engama-30).

Ukuhlola ukuhlukunyezwa kwamakhala kubonise ukuthi ukusetshenziswa kwe-SAIB kwenyusa usayizi wempushana ngesikhathi sokugaya, kuze kufike ku-47% wosayizi wempushana wokugaya omkhulu kuno-1mm.

Uma kuqhathaniswa neqembu elilawulayo, inani elikhishwayo le-SAIB emanzini, 0.1%N HCl kanye nezincibilikisi ezingu-0.1%N NaOH lehle ngo-41.3% -42.5%, 24.8% -26.1% no-37.4% -50.6%, ngokulandelana. Ukusetshenziswa kwezinyibilikisi zemvelo ukuze kukhishwe kukhiqiza izinsalela ezinamathelayo okunzima ukudlula kuzo ezindleleni ezihlukahlukene zokuphatha (isb., umjovo, ukumunca, ukuhonqa, njll.), ukuvimbela ukusetshenziswa kabi kwezidakamizwa.

isiphetho

Ukusetshenziswa kwe-SAIB, ngaphandle kokumbozwa, kungaxutshwa ngokuqondile ne-API ukuze kwelule ukukhululwa kwezidakamizwa futhi kuzuzwe ukukhululwa okuqhubekayo.

I-Hydrophobic SAIB, engahlakazwa emanzini ngosizo lwezincibilikisi eziphilayo, ingasetshenziswa nge-hydrophobic noma i-hydrophilic apis; I-SAIB ingathuthukisa ukunyibilika kwe-API ngokungancibiliki kahle kwamanzi futhi iyisincibilikisi esihle kakhulu nesithwali se-API esinokuncibilika okuncane kwamanzi.

Ukusetshenziswa kwe-SAIB kuvimbela ukusetshenziswa kabi kwezidakamizwa ngokwandisa usayizi wezinhlayiyana zomuthi lapho usucolile, ukuphazamisa ukukhishwa kwezidakamizwa, futhi kwenze kube nzima ukuthi umuthi umunce ngezindlela ezihlukahlukene zokuphatha.

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