I-Youdaoplaceholder0 1.1 Umlingo obonakalayo we-viscosity gradient: Ukuguqulwa okuphindwe kathathu ukusuka eSiswini kuya kukholoni

Isakhiwo samangqamuzana e-polyglucose sakhiwe izinsalela ze-glucose ezixhumene ngokungahleliwe, futhi lokhu kuhlanganiswa okukhethekile kuyinikeza izici eziyingqayizivele ze-rheological. Esimeni esine-acidic kakhulu yesisu (pH 1.5-3.5), amaketanga aso amangqamuzana akha ngokushesha ukwakheka kwenethiwekhi enezinhlangothi ezintathu ngokusebenzisa amabhondi e-hydrogen, futhi i-viscosity ikhuphuka ngokushesha ibe yi-1200 mPa·s (cishe ephindwe kabili kuneyoju), ibambezeleka ngempumelelo izinga lokuthulula esiswini ngokufika ku-40% wokugcwala nokugcwala. Ngemva kokungena emathunjini amancane, njengoba inani le-pH likhuphukela ku-6.0-7.5, amanye amabhondi e-hydrogen ayaphuka futhi i-viscosity yehla ibe ngu-300-500 mPa·s. Ayikuvimbeli ngokweqile ukumuncwa kwezakhi futhi ayihlanganisi nama-bile acid ukwehlisa izinga lokumuncwa kwe-cholesterol. Lapho ufinyelela ikholoni, ngaphansi kwesenzo sokuvutshelwa kwe-microbial, i-viscosity iyancipha futhi ibe ngaphansi kwama-50 mPa·s, ikhulula ama-fatty chain acids amancane (ama-SCFAs) ukuze anikeze amandla kuma-probiotics (Umfanekiso 1).

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Usekelo lwedatha ye-Youdaoplaceholder0 :

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Izinga lokulibaziseka lokukhipha isisu: 40% (I-Hydrocolloids Yokudla 2022, n=30)

Izinga lokuvimbela ukumuncwa kwe-cholesterol: 22% (idatha yesitifiketi se-GRAS evela e-US FDA)

Ukukhiqizwa kwama-SCFA okukhulisiwe: Ukugxiliswa kwe-acetic acid ye-Colonic kukhuphuke izikhathi ezingu-3.8 (I-Gut 2023, Imodeli Yezilwane)

I-Youdaoplaceholder0 1.2 Isu elithi "Precision feeding" le-microbiome

Ukulawulwa kwe-viscosity ye-polydextrose ayithinti kuphela inqubo yokugaya umzimba, kodwa futhi yakha ukusebenzisana okunamandla nezitshalo zamathumbu. Isimo se-viscosity esiphezulu sakha umgoqo womzimba ku-colon proximal, ukunciphisa ukuthintana phakathi kwamabhaktheriya e-pathogenic kanye ne-mucosa yamathumbu. Njengoba i-viscosity iyancipha, kancane kancane ishintsha ibe i-substrate evubelayo, ikhuthaza ngokukhethekile ukwanda kwe-Bifidobacteria kanye namagciwane e-lactic acid. Ithimba elivela eNyuvesi yaseCambridge lithole ngokulandelana kwe-metagenomic ukuthi ukudla okuqhubekayo kwe-12g/ngosuku ye-polydextrose amaviki angu-8 kungase kukhulise isilinganiso se-F/B se-Thick-miliae/Bacteroidetes sibe ngu-1.3 (ngesisekelo esinempilo esingu-1.5-2.0), futhi kwandise ukuchichima kwe-acidity ye-butcalium njenge-bacterisic acid (5%). Lo mphumela wezigaba ezimbili "wokuzivikela kuqala, bese ukondliwa" uhlangabezana ngokuphelele nezidingo zemvelo zezingxenye ezahlukene zepheshana lamathumbu.

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Youdaoplaceholder0 Isahluko 2 Isicelo Scenario Revolution: Ukungena Okunqamula Umngcele kusuka Ukudla Okulawulwa Ushukela kuya ICU Nutrition

I-Youdaoplaceholder0 2.1 Imboni Yokudla: "I-skeleton engabonakali" yemikhiqizo ye-Low GI

Emkhakheni wokubhaka, umthamo omkhulu wokubamba amanzi (> 8g amanzi/g) kanye nokuzinza okushisayo (ukubekezelela ukuya ku-200℃) we-polyglucose kuyenza ibe indawo ekahle ye-sucrose. I-"Zero Sugar Cookies" eyethulwe i-Meiji Group yase-Japan isebenzisa i-polyglucose njengefayibha eyinhloko, ithola kuphela u-1.2g wenet carbohydrates ngekhukhi ngalinye, futhi ukuthungwa nokucwebezela akuhlukile kulezo zemikhiqizo equkethe ushukela. Okubaluleke nakakhulu, ukulawulwa kwayo kwe-viscosity emathunjini amancane kungabambezela ukumuncwa kwe-glucose futhi kunciphise inani eliphakeme le-glucose yegazi le-postprandial ngama-34% (idatha yomtholampilo evela ku-Diabetes Care 2021).

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I-Youdaoplaceholder0 Icala le-Innovative :

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I-Youdaoplaceholder0 Nestle : "Ibha yamandla ekhishwa kancane eSmart" ethuthukiswe ngokuhlanganisa i-polydextrose ne-dextrin engazweli ifaka idizayini ye-viscosity gradient enweba ukumuncwa kwe-carbohydrate ibe amahora angu-6, ehlangabezana nezidingo eziqhubekayo zokuphakelwa kwamandla zabagijimi bemarathon.

I-Youdaoplaceholder0 I-Nongfu Spring : Kwethulwe "Amanzi Anamandla Angaphakathi Amanzi Akhazimulayo" ane-polyglucose engeziwe, esebenzisa indawo yayo yokuvubela ene-viscosity ephansi ukuze kukhiqizwe igesi epholile kukholoni ukuze kushukumise ukubola kwamathumbu. Idayise amabhodlela angaphezu kwezigidi ezingu-100 ngezinyanga ezintathu.

I-Youdaoplaceholder0 2.2 Umsoco wezokwelapha: "I-intestinal barrier Guard" yeziguli zase-ICU

Ukwehluleka kwesithiyo se-mucosal emathunjini ezigulini ezigula kakhulu kuvame ukuholela ezifweni zesistimu. Uhlolo olulawulwa ngokungahleliwe (n=158) olwenziwa Isibhedlela Esisebenzisanayo Sokuqala sase-Zhejiang University lubonise ukuthi iziguli ze-ICU ezazenezelwa ngo-15g we-polyglucose nsuku zonke zibe nokwehla okungama-42% kwezehlakalo ze-endotoxemia kanye nokwehliswa okungama-29% kunkomba yokuvuvuka kwamathumbu (i-plasma ligonin). Umshini uwukuthi isimo se-viscosity esiphezulu sakha ifilimu yokuzivikela esiswini, ukunciphisa ingozi yezilonda ezibangelwa ukucindezeleka. I-asidi ye-butyric ekhishwe ingxenye ye-colon ikhuthaza ngokuqondile ukushuba kongqimba lwamafinyila (ukwandisa inani lamaseli egobolondo ngo-37%), kuzuzwe ukuqiniswa kwesithiyo esimbaxambili somzimba namakhemikhali.

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I-Youdaoplaceholder0 Isahluko 3 Ukuphumelela Kwezobuchwepheshe: Ukuthuthuka kusuka ku-'Empirical Formulas' kuya ku-' Computational Nutrition '

I-Youdaoplaceholder0 3.1 Ukulawulwa okunembile kokuguqulwa kwamangqamuzana

Uhla lwempendulo ye-viscosity ye-polydextrose yendabuko inomkhawulo, okwenza kube nzima ukufanisa ngokunembile izimfuno zomuntu ngamunye. NgoJuni 2023, i-DSM yaseNetherlands yamemezela ubuchwepheshe bayo obunelungelo lobunikazi i-"PolySmart?", eyathuthukisa izinhlobo ezintathu ze-viscosity curve ngokulawula izinga le-polymerization (i-DP value) ye-glucose ne-sorbitol:

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Uhlobo lwe-Youdaoplaceholder0 G (ukuthuthukiswa kwesisu) : I-Viscosity efika ku-1500 mPa·s ku-pH

Uhlobo C lwe-Youdaoplaceholder0 (okuhloswe ngalo ngekholoni) : I-Viscosity yehla kakhulu ifike ku-30 ??mPa·s ku-pH > 6.5, ikhethwa kubantu abanokuqunjelwa;

I-Youdaoplaceholder0 Type B ? (imodi elinganiselayo) : Ukuguqulwa okushelelayo kwe-viscosity yamathumbu isiyonke, ifanele ukulawulwa kweglucose yegazi ezigulini ezinesifo sikashukela.

I-Youdaoplaceholder0 3.2 I-AI-Assisted Formulation design

Inkundla ye-"FiberEngine" eyakhiwe inkampani yakwa-Israel i-NutriAI ihlanganisa idatha ye-gut microbiota eyizigidi ezi-2 kanye namamodeli we-fluid dynamics, engabikezela inani eliphelele lokwengezwa kwe-polydextrose ngaphansi kweminyaka ehlukene nezimo zezifo. Isibonelo, ezigulini ezine-IBS (Irritable Bowel Syndrome), uhlelo luncoma inhlanganisela yansuku zonke ye-8-10g ye-polyglucose kanye ne-2g ye-fructooligosaccharides, enciphisa izehlakalo zokuphazamiseka kwesisu ngo-65% (idatha yokulandelela yomsebenzisi ka-2023).

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I-Youdaoplaceholder0 Isahluko 4 Sezinxushunxushu: "I-Fiber Blue Ocean" ama-Giants ayilwelayo

I-Youdaoplaceholder0 4.1 Umjaho wamandla uyashisa

Usayizi wemakethe ye-polydextrose yomhlaba wonke kulindeleke ukuthi ukhule usuka ezigidini ezingama-870 zamadola aseMelika ngo-2023 uye kumadola ayizigidi eziyizinkulungwane ezingama-2.1 ngo-2030 (CAGR 12.3%). I-China isiphenduke inkundla yempi eyinhloko.

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I-Youdaoplaceholder0 Baolingbao Bio : Tshala izigidi ezingu-500 zamayuan ukuze wandise amathani angu-30,000 ngonyaka wokukhiqiza, usebenzisa inqubo ye-enzymatic synthesis ukuze uzuze ubumsulwa obungama-99.5%;

I-Youdaoplaceholder0 Rogate : Ama-microcapsules e-Probiotic-polyglucose athuthukiswe ngokubambisana ne-CHR. U-Hansen ukhuphule izinga lokusinda elimelana ne-asidi laya ku-90%;

I-Youdaoplaceholder0 Matsuya Chemie, Japan : Kwethulwe "i-nano-fibrotic polyglucose," enamandla okuzwela okuphindwe kathathu kwe-viscosity regulation futhi inikezwe igama lesidakamizwa esiyintandane yi-FDA yesifo samathumbu amafushane.

I-Youdaoplaceholder0 4.2 Izinselelo ezikabili zokulawula nokuqonda

Nakuba i-polydextrose ivunyelwe njenge-fiber yokudla yi-European Union, i-China namanye amazwe, abathengi basenokungaqondi kahle. Ucwaningo olwenziwa yi-FMCG e-United States lubonisa ukuthi amaphesenti angama-28 kuphela abathengi abangakwazi ukuhlukanisa kahle umehluko wokusebenza phakathi kwe-polydextrose nesitashi esingazweli. Okubi nakakhulu, ukudla ngokweqile (> 50g/ ngosuku) kungase kubangele ukungezwani kwesisu noma kuphazamise ukumuncwa kwamaminerali. Imboni idinga ukusungula imihlahlandlela yomthamo ojwayelekile.

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I-Youdaoplaceholder0 Isahluko 5 Sibheke phambili: "Inethiwekhi ye-fiber" esuka ku-GUT iye Ezempilo Yomzimba

I-Youdaoplaceholder0 5.1 Ubufakazi obusha bokulawulwa kwe-axis yobuchopho-amathumbu

Ekuqaleni kuka-2024, i-California Institute of Technology yathola ocwaningweni lwamagundane ukuthi i-asidi ye-butyric ekhiqizwa ukuvutshelwa kwe-polydextrose ingashukumisa ama-hypothalamic neurons ngokusebenzisa i-vagus nerve, inciphise ukuziphatha okufana nokukhathazeka ngama-43%. Lokhu kunikeza incazelo yezinga le-molecular yesimangalo sokuthi "ukudla okune-fiber ephezulu kuthuthukisa impilo yengqondo".

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I-Youdaoplaceholder0 5.2 Izinto Ezintsha Eziphazamisayo ku-Synthetic biology

Isiqalisi sase-US i-Zymergen sisebenzise ubuchwepheshe be-CRISPR ukuze iguqule i-Trichia pastoris, iyenze ikwazi ukukhiqiza ngokuqondile "i-polyglucose ehlelwe ngofuzo" ngejika le-viscosity elenziwe ngokwezifiso. Lo mkhiqizo ubonise ukuthuthuka okungama-80% ekuphenduleni kwe-pH okunembayo ekuhlolweni kokugaya okulingiswayo futhi kulindeleke ukuthi ungene esigabeni sesilingo somtholampilo ngo-2025.

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I-Youdaoplaceholder0 Isiphetho: Ukuchaza kabusha "imingcele ehlakaniphile" ye-Fiber

Umphumela we-viscosity gradient we-polydextrose uphawula inkathi entsha ye-fiber yokudla, isuka "ku-passive supplement" iye "ekulawuleni okusebenzayo". Lapho ingxenye yefayibha ingakwazi ukulawula ukusebenza kwayo ngokuzimele ekuphenduleni imvelo yomgudu wokugaya ukudla, kungenzeka sibona ukushintsha kwepharadigm kusayensi yezokudla - ukungenelela kwezempilo kwesikhathi esizayo ngeke kusaba imizamo yodwa ye-molecule eyodwa, kodwa kunalokho kuzoba umdanso wokuhlanganyela wezinto ezihlakaniphile, i-microbiome, nobuhlakani bokwenziwa. Njengoba owawina uMklomelo KaNobel kuKhemistry, uFrances Arnold, wake wathi, "Ama-molecule emvelweni asevele abambe amathuba angapheli. Okufanele sikwenze ukufunda ukulalela 'ulimi lwawo lwesikhathi nendawo'."