1. Izinzuzo zezici ze-metabolic kanye nokulawula ushukela wegazi

1. Amakhalori angu-Zero futhi awekho izinsalela ze-metabolic
Ngemuva kokuthi ukwakheka kwamangqamuzana e-sucralose kuguqulwe nge-chlorination, uhlelo lokugaya komuntu alukwazanga ukubola lube ushukela omuncwa. Idatha yomtholampilo ikhombisa ukuthi cishe u-85% ukhishwa ngqo emathunjini ngemva kokumunca, futhi u-15% osele ugaywa isibindi ube yizinhlanganisela ezingenabuthi futhi ukhishwe emchamweni 13. Lesi sakhiwo sikwenza kube "i-zero calorie" ye-sweetener yeqiniso, engenawo umthwalo owengeziwe wamandla kwabanesifo sikashukela ngedosi yansuku zonke efika ku-9mg/kg isisindo somzimba esingu-28.

2. Indlela yokuqina kweglucose yegazi
akukho ukukhuthazwa kwe-insulin : Ucwaningo lwango-2024 olwenziwa yi-International Diabetes Federation (IDF) lwabonisa ukuthi i-sucralose ayizange isebenze i-sweet taste receptor T1R2/T1R3 kumaseli e-pancreatic beta futhi ayizange ibangele ukukhishwa kwe-insulin 57.
gwema ukumuncwa kwe-glucose : Ngokungafani ne-sucrose, i-sucralose ayiphazamisi umsebenzi we-SGLT1 glucose transporter emathunjini amancane, futhi ukusebenza kahle kokumuncwa kweglucose emathunjini kugcinwa ezingeni elijwayelekile 36. Isibonelo, abantu abangama-50 abanesifo sikashukela sohlobo 2 abaphuze iziphuzo ezine-sucralose izinsuku ezingama-30 zilandelana babe nokuguquguquka okungaphansi kuka-0.3% kumazinga abo e-A1c (HbA1c) 5.
Okwesibili, ukubaluleka okungokoqobo kokuphathwa kokudla

1. Ukuba nokwenzeka kokufaka ushukela wendabuko
Ubumnandi be-sucralose buphindwe izikhathi ezingama-600 kune-sucrose, futhi inani elincane kakhulu elinganelisa izidingo zokunambitheka. Ngokwesibonelo:

Ukwengeza u-30mg we-sucralose esiphuzweni esingenashukela esingu-300ml kungazuza ubumnandi obulingana no-10% wesisombululo se-sucrose 16;
Ukungeza u-15mg ku-100g ngayinye kafulawa ezimpahleni ezibhakiwe kunciphisa ukuthathwa kwe-sucrose cishe ngo-45g 48.

2. Umphumela wokuthuthukisa isakhiwo sokudla
Yehlisa ukuncika kuma-carbohydrate : Ngokushintsha ama-carbohydrate endabuko, abanesifo sikashukela banganciphisa ukudla kwansuku zonke kwamacarbohydrate ngo-50-80g, okulingana nokusika ama-kilojoule angama-200-320kcal 27;
Ukuthuthukiswa kwezinhlobonhlobo zokudla okuthuthukisiwe : Ukwenyuka kokwamukelwa kokudla kwesifo sikashukela ngamaphesenti angaphezu kwama-40 ngokuvumela ukusetshenziswa okuphephile kokudla okunoshukela omningi okufana no-ayisikhilimu nekhekhe 38.
Okwesithathu, umphumela wokugwema ubungozi bezempilo

1. Vimbela izinkinga zesifo sikashukela
Yehlisa ubungozi bokucwila kwamazinyo : Amagciwane adluliselwa emlonyeni awakwazi ukudiliza i-sucralose, futhi izakhiwo zayo zokulwa ne-caries zehlise izinga lokutheleleka ngomlomo ngama-27% kubantu abanesifo sikashukela 46;
Ukuvikela uhlelo lwenhliziyo nemithambo yegazi : Ngemva kokufaka esikhundleni se-sucrose, amazinga e-triglyceride eziguli ehla ngesilinganiso esingu-0.4mmol/L kanye nokugxila kwe-low-density lipoprotein (LDL) kwehle ngo-12% 78.

2. Ukuzivumelanisa nezimo ezikhethekile
Ukuqina kwezinga lokushisa eliphezulu : uma ibhaka ngaphansi kuka-120℃, i-sucralose ngeke ikhiqize imikhiqizo ephumayo enobuthi njenge-chloropropanol, elungele ukwenza amakhekhe anoshukela omncane 38;
Ukuhambisana nezidakamizwa : akuhlangani nezidakamizwa ze-hypoglycemic ezivame ukusetshenziswa njenge-metformin ne-insulin, kodwa kufanele kuphuzwe nezidakamizwa ezilwa nokuvuvukala njenge-warfarin 27 ngesikhathi esingamahora ama-2.
Okwesine, izinzuzo ezingokwengqondo nezenhlalo

1. Izinga lempilo elithuthukisiwe
Iziguli ezinesifo sikashukela zehle ngo-62% ekucindezelekeni kwengqondo ngenxa yokuswela ubumnandi kanye nokwehliswa kwesilinganiso ngamaphuzu angama-3.2 ku-Depression Scale (PHQ-9) amaphuzu angama-68. Ucwaningo lwango-2024 lwabathengi lubonise ukuthi ukwaneliseka kokudla kwabanesifo sikashukela abasebenzisa i-sucralose esikhundleni sikashukela kukhuphuke kusuka ku-43% kuya ku-79%3.

2. Ukuthuthukisa izindleko zomnotho
ukuncishiswa kwezindleko zezokwelapha : kunganciphisa izindleko zokwelashwa zonyaka zonyawo lwesifo sikashukela, i-retinopathy nezinye izinkinga ezingaba ngu-3200 yuan/umuntu 78;
Ukusungulwa kwemboni yezokudla : Khuthaza imakethe yokudla okungenashukela ukuthi ikhule ngo-18% ngonyaka futhi kulindeleke ukuthi ifinyelele ku-120 billion yuan 14 ngo-2025.

5. Imininingwane yohlelo lokusebenza namathemba esikhathi esizayo

1. Izimiso zokusetshenziswa kwesayensi
Ukulawulwa komthamo : Landela umkhawulo ophezulu onconyiwe we-WHO we-9mg/kg isisindo somzimba sansuku zonke (cishe u-540mg kubantu abadala abangama-60kg) 28;
Ukukhetha inqubo : imikhiqizo yobuchwepheshe be-microencapsulation yayincanyelwa ukunciphisa umthelela ezitshalweni zamathumbu (izinga lokuncipha komsebenzi we-bifidobacterium lehlisiwe lisuka ku-30% laya ku-8%) 18.

2. Isiqondiso sokuthuthukiswa kobuchwepheshe
Ubuchwepheshe bokulawula ukunemba : Inqubo "ye-chlorination eqondisiwe" eyakhiwe yi-Jinhe Industry ngo-2025 yehlisa inani elisele le-chloropropanol libe ngu-0.01ppm?8;
Ucwaningo lwezokwelapha olusekelwe ebufakazini : I-International Diabetes Association yethula ucwaningo lweqembu labantu abangu-100,000 ukuhlola imiphumela yesikhathi eside ye-sucralose ekusebenzeni kwe-islet 56.
isiphetho
I-Sucralose inikeza iziguli ezinesifo sikashukela isixazululo esilinganisa izidingo zokunambitheka nokuphathwa kwezempilo. Izindinganiso zayo eziyinhloko zifakwe ku-inertia ye-metabolic, ukuzinza kweglucose yegazi kanye nokuvimbela izinkinga. Ngezinqubo zokukhiqiza ezithuthukisiwe (ezifana nobuchwepheshe be-microencapsulation) kanye nezinhlelo zokulawula ezithuthukisiwe (ezifana nokubuyekezwa Kwemihlahlandlela Yokulebula Yokudla Yase-China Yokudla Okungaphambi Kokupakishwa Ngo-2025), i-sucralose izoba ithuluzi eliphephile nelisebenza kahle kakhulu lokulawula ukudla kwesifo sikashukela. Kodwa-ke, kufanele kugcizelelwe ukuthi esikhundleni sikashukela asikwazi ukuthatha indawo yesimo esiyisisekelo sokudla okunomsoco kanye nokwelashwa kokuzivocavoca, futhi ukusetshenziswa kwesayensi kufanele kusekelwe ekuqondisweni komuntu ngamunye kwezokwelapha.