Umphumela we-mannose kushukela wegazi mncane kakhulu, futhi kungathiwa "awunawo umthelela" emazingeni kashukela egazini. Lona umehluko oyinhloko phakathi kwawo namanye amashukela amaningi njengeglucose.

Nansi incazelo enemininingwane:

Izindlela ezahlukahlukene ze-metabolic:

IGlucose: Iwumthombo oyinhloko wamandla omzimba. Imuncwa kahle emathunjini (cishe i-100%), ingena egazini (inyusa ushukela wegazi), futhi ithathwe, isetshenziswe, noma igcinwe ngamaseli ngosizo lwe-insulin (njenge-glycogen, amafutha).

I-Mannose: Nakuba iyi-monosaccharide (i-carbon sugar eyisithupha), indlela yayo yokugaya emzimbeni ihluke ngokuphelele kushukela.

Izinga lokumuncwa eliphansi: Ukusebenza kahle kwamathumbu emannose kuphansi kakhulu kuneglucose (cishe ama-20% kuphela noma ngaphansi).

Ayincikile ku-insulin: Ngemva kokumuncwa esibindini, iningi le-mannose lifakwa i-phosphorylated libe yi-mannose-6-phosphate ngama-enzyme athile (ikakhulukazi i-mannose kinases).

Ukuguqulwa ku-Fructose-6-phosphate: I-Mannose-6-phosphate kamuva iguqulelwa ku-Fructose-6-phosphate nge-phosphomannose isomerase.

Ukungena emgudwini we-glycolysis: I-Fructose-6-phosphate iwumkhiqizo omaphakathi osendleleni ye-glycolysis ongaphinde ugaywe nge-metabolism ukuze ukhiqize amandla. Okubalulekile ukuthi le nqubo yokuguqula idlula izinyathelo ezibalulekile njenge-glucokinase ne-glucose-6-phosphate, futhi ayincikile esenzweni se-insulin. .

Akukhuthazi ukukhiqizwa kwe-insulin:

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Ngenxa yokuthi i-mannose ngokwayo ayisona isikhuthazi esikhulu soshukela wegazi ophakeme (ngenani elincane elingena egazini kanye nezindlela ezihlukene ze-metabolic), ayiwakhuthazi kakhulu amangqamuzana e-beta e-pancreatic ukuthi akhiphe i-insulin njengeglucose. Ucwaningo luye lwabonisa ukuthi ukuphathwa ngomlomo kwe-mannose akukhulisi kakhulu i-glucose yegazi kanye namazinga e-insulin.

Ubufakazi bomtholampilo nobokuhlola:

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Inani elincane locwaningo olwenziwe kubantu abanempilo kanye neziguli ezinesifo sikashukela sohlobo 2 libonise ukuthi ngisho nangemithamo ephezulu kakhulu (efana ne-0.2 g/kg isisindo somzimba, esilingana ne-14 g kumuntu ongu-70 kg), i-mannose yomlomo ayizange ibangele ukushintshashintsha okukhulu kumazinga eglucose egazini.

Ukuhlolwa kwezilwane nakho kubonise ngokungaguquki ukuthi i-mannose ayiwanyusi amazinga kashukela egazini.

Fingqa izizathu zokuthi kungani i-mannose inomthelela omncane kushukela wegazi:

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Izinga lokumunca eliphansi: Iningi le-mannose elimunyiwe alimuncwe futhi lisetshenziswa ngokuqondile noma likhishwe amagciwane amathumbu.

Indlela ehlukile ye-metabolic: Ingxenye emunnyiwe iguqulwa ngokushesha ibe i-fructose-6-phosphate esibindini ngokusebenzisa indlela ezimele ye-insulin bese ingena ku-glycolysis, igwema ukujikeleza okuqondile njengeglucose yegazi (glucose).

I-insulin engakhuthazi: Ukuntuleka kokukhuthazwa okusebenzayo koshukela wegazi, ngakho-ke ayibangeli ukukhiqizwa kwe-insulin okubalulekile.

Isaziso Esibalulekile:

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Umthamo: Iziphetho ezingenhla zisekelwe kakhulu kumithamo eyengeziwe eyengeziwe (evame ukusetshenziselwa izinjongo zempilo yomchamo, cishe amagremu angu-1-2 ngosuku) kanye neminye imithamo yocwaningo (efana no-0.2g/kg). Ngokombono, imithamo ephezulu kakhulu ingase ikhiqize imithwalo ehlukene ye-metabolic, kodwa ngokuvamile ayisetshenziselwa le njongo.

Ubumnandi: Ubumnandi bemannose bucishe bufinyelele ku-70% be-sucrose, kodwa ngezinye izikhathi bubizwa ngokuthi "i-low glycemic index sweetener" ngoba ayithinti ushukela osegazini futhi imunca kancane. Kodwa izindleko zayo kanye nokunambitheka (okubabayo kancane) njenge-sweetener kunciphisa ukusetshenziswa kwayo okusabalele.

Ukusetshenziswa okuyinhloko: Okwamanje, ukusetshenziswa okuyinhloko kwe-mannose kusekelwe ekhonweni layo lokuphazamisa ukunamathiselwe kwamagciwane (ikakhulukazi i-Escherichia coli) kumaseli e-epithelial emgudwini womchamo, ukuvimbela nokwelashwa kwezifo zomgudu womchamo (UTIs). Izici zayo ezinobungane kushukela wegazi zikwenza kube ukukhetha okuphephile uma kuqhathaniswa ezigulini ezinesifo sikashukela noma abantu abalawula ushukela wegazi lapho bedinga ukuvimbela ukutheleleka komgudu womchamo (Yebo, kusadingeka balandele iseluleko sikadokotela).

Umehluko ngamunye kanye nokubonisana nodokotela: Nakuba izindlela ze-metabolic zinquma ukuthi akuthinti ushukela wegazi, kungase kube khona umehluko phakathi kwabantu ngabanye. Uma unesifo sikashukela esibi kakhulu noma ezinye izifo ze-metabolic, kungcono ukubonana nodokotela ngaphambi kokusebenzisa i-mannose njengesengezo.

Isiphetho:

I-Mannose ingushukela okhethekile okuthi, ngenxa yezinga lawo eliphansi lokumunca emathunjini kanye nendlela ehlukile ye-insulin ye-metabolic esibindini, ingabangeli neze ukwenyuka kwamazinga kashukela egazini futhi ayikukhuthazi ukukhishwa kwe-insulin. Lokhu kwenza kuphephe kakhulu kubantu abadinga ukulawula ushukela egazini (njengeziguli ezinesifo sikashukela) kunabanye ushukela, ikakhulukazi uma usetshenziselwa ukuvimbela izifo zomgudu womchamo.