Ca HMB, igama eligcwele elithi β-hydroxy-β-methylbutyrate calcium, ingenye yezindlela ezivamile zokwengeza ze-HMB (β-hydroxy-β-methylbutyrate). I-Beta-hydroxy-beta-methylbutyric acid (HMB) itholakala kakhulu esithelweni esisawolintshi nemifino ethile efana ne-broccoli, imidumba efana ne-alfalfa, nezinhlanzi ezithile kanye nezilwane zasolwandle. I-β-hydroxy-β-methylbutyrate calcium (Ca HMB) iwusawoti we-calcium we-β-hydroxy-β-methylbutyrate (HMB). Ngenxa yesimo esisebenzayo se-HMB, ukuze kube lula ukugcinwa nokusetshenziswa, ngokuvamile iguqulwa ibe usawoti we-calcium lapho ihlanganiswa, futhi ingxenye eyinhloko yokuqukethwe kwe-HMB isukela ku-77-82%.

I-HMB iyi-metabolite emaphakathi ye-amino acid leucine yomuntu ebalulekile, futhi umzimba womuntu ungakhiqiza inani elincane le-HMB uqobo. Ekudleni okuvamile, umzimba womuntu ukhiqiza cishe ama-300 kuya ku-400 mg ngosuku, lapho ama-90% avela ku-catabolism ye-leucine. I-HMB ingasetshenziselwa ukukhuthaza ukukhula kwemisipha, ukuthuthukisa ukuzivikela komzimba, ukunciphisa i-cholesterol kanye namazinga aphansi e-lipoprotein e-density emzimbeni ukunciphisa ukuvela kwesifo senhliziyo nesifo senhliziyo, kodwa futhi ukuthuthukisa ikhono lomzimba lokulungisa i-nitrogen, ukugcina amazinga amaprotheni emzimbeni, nokuvimbela ukubola kwemisipha ezigulini ezilele embhedeni noma ezikhubazekile. Eminyakeni yamuva, ngenxa yokuthi inganciphisa ukulimala kwezicubu ze-muscle ngemva kokuzivocavoca, ukulungisa izintambo ze-muscle, ukwandisa amandla emisipha nokushisa amafutha omzimba, isibe isithako senkanyezi emikhiqizweni yokudla kwezemidlalo. Ngaphezu kwalokho, i-HMB ifakazelwe ngokomtholampilo ukuthi isheshisa ukuphulukiswa kwesilonda futhi ivimbele ukuvuvukala. Ucwaningo lubonise ukuthi i-Ca HMB ingasheshisa ukuhlanganiswa kwamaprotheni futhi ibambezele ukusetshenziswa kwamaprotheni. I-Ca HMB ehlanganiswe ne-glutamine ne-arginine ingathuthukisa ibhalansi ye-nitrogen engeyinhle yeziguli futhi idlale indima enhle ekululameni ekuhlukumezekeni nasekuhlinzweni.

Ngo-2011, uMnyango Wezempilo wangaphambili waseChina wamemezela ukugunyazwa kwe-β-hydroxy-β-methylbutyrate calcium (Ca HMB) njengokudla kwensiza entsha, ukusetshenziswa kokudla okunomsoco wezemidlalo, ukudla kwefomula ekhethekile yokusetshenziswa kwezokwelapha, inani elinconyiwe ngu-≤3 amagremu/ngosuku. Ngo-2017, Ikhomishana Kazwelonke Yezempilo Nokuhlela Umndeni yamemezela ukwanda kobubanzi bokufaka isicelo se-Ca HMB kusukela ezicelweni ezimbili zokuqala ukuya kweziyisishiyagalolunye, futhi yagunyaza izikhungo zobuchwepheshe zokuhlola ubungozi ukuba zenze ukuhlola kokuphepha. Ukusetshenziswa kwe-Ca HMB kwanwetshwa ukuze kufakwe iziphuzo, ubisi nemikhiqizo yobisi, imikhiqizo kakhokho, ushokoledi nemikhiqizo kashokoledi, uswidi, izinto ezibhakiwe, nokudla okukhethekile okudliwayo, futhi inani elinconyiwe lalisengu-≤3 g/ngosuku, elingazange lidlule umthamo wamavolontiya esilingo sabantu. I-Ca HMB yaqashelwa njenge-GRAS yi-US Food and Drug Administration ngo-1995 futhi isetshenziswa ekudleni okunomsoco wezokwelapha kanye nokudla okukhethekile. Eminyakeni engu-20 edlule, i-Ca HMB ibisetshenziswa kabanzi emikhiqizweni yobisi, imikhiqizo kashokoledi, iziphuzo, izindawo zamandla nokunye ukudla emakethe yase-US. I-Ca HMB iwukudla okuluhlaza okuvunyelwe yimithetho yaseJapan, engangezwa emikhakheni eminingi efana nokudla okuvamile, ukudla okunomsoco wezemidlalo, ukudla okwehlisa isisindo, ukudla kobuhle, njll. Ingasetshenziswa futhi njengesithako esisebenzayo ezithasiselweni zokudla ezifana namaphilisi, amaphilisi, iziphuzo eziqinile. Kubakhiqizi namakhemisi, i-Ca HMB njengamanje ingesinye sezithako zezempilo ezidume kakhulu emakethe yaseJapan.

I-HMB isetshenziswa kabanzi eziphuzweni eziqinile, futhi imikhiqizo enjalo nayo iyichichima emakethe yamazwe ngamazwe. Isibonelo, u-Juven wethulwe ngu-Abbott ukuze akhuthaze ukuhlanganiswa kwamaprotheni, i-Myoplex Muscle Armor eyethulwe i-EAS e-United States, i-Fracora yezempilo yemisipha yabadala ekhiqizwe i-Concord e-Japan, njll., konke kusekelwe ku-HMB njengento esetshenziswayo eluhlaza. Eziphuzweni eziwuketshezi ze-HMB, isicelo sasekhaya sisesigabeni sokuqala, kodwa izinkampani zakwamanye amazwe zisisebenzisile futhi zisezinhlelweni zokuthuthuka kancane kancane. Isibonelo, isiphuzo sezemidlalo i-SUISPO yethulwe yinkampani yaseJapan i-ISDG, kanye noketshezi lomlomo lobuhle olwethulwe yiJapan Concord. Njengokudla okusha okungase kufakwe eziphuzweni, i-HMB ingahlanganiswa nezinhlobonhlobo zamaprotheni, njenge-whey protein concentrate, i-milk protein concentrate, i-whey protein isolate, nephrotheni yemifino, futhi ingasetshenziswa nokwakhiwa kwamavithamini namaminerali ukuze kwandiswe ukusebenza komkhiqizo. Ubisi oluwuketshezi kanye nobisi oluyimpushana olune-HMB lungasetshenziswa kubantu abaneminyaka ephakathi kanye nabantu asebekhulile ukusiza ukuvimbela ukubola kwemisipha, futhi lungasetshenziselwa abantu bezemidlalo kanye nokuqina ukuze banikeze isithasiselo sokudla okunempilo kwemisipha. Ngaphezu kwalokho, enye iyogathi esebenzayo emakethe, ukwengeza i-HMB kungathuthukisa umqondo womkhiqizo wokuqala futhi kunikeze umqondo wokunciphisa amafutha kanye nokubunjwa komumo, futhi ukwengeza izinto ezisetshenziswayo zokusetshenziswa ku-ayisikhilimu nakho kuyindlela emisha yabakhiqizi abaningi bakwa-ayisikhilimu bangaphandle. Ukwengeza izithako ze-HMB kungaqinisa ukusebenza kahle kuka-ayisikhilimu esimisweni sokuqinisekisa ukunambitheka nokunambitha. Ngaphezu kwalokho, i-HMB ingasetshenziswa futhi emigoqweni yokudla okunomsoco namaswidi, njengomkhiqizo odume kakhulu webha yokudla okunomsoco i-Maximuscle, enezela amagremu angu-20 amaprotheni, amagremu angu-3.4 we-creatine monohydrate kanye namagremu angu-1.6 we-HMB, okukhangiswa ukuze kuncishiswe ukuwohloka kwamaprotheni, kwakha imisipha ngenkathi kukhuthazwa ukululama ngemva kokuzivocavoca umzimba. Abathuthukisi bokudla bokulahlekelwa kwamafutha kudala basebenzisa i-HMB kumaswidi, njengenkampani yaseJapane i-ISDG ekhiqizwayoHMBuswidi, okuwuswidi wabantu abakha izicubu zomzimba futhi balahlekelwe namafutha.

Njengokungenelela okunomsoco okuphumelelayo kokuvimbela nokwelashwa kwe-muscular decay syndrome,HMBkuye kwaqinisekiswa yinani lezifundo zomtholampilo, futhi i-HMB iye yafakazelwa ngokomtholampilo ukusheshisa ukuphulukiswa kwesilonda nokuvimbela ukuvuvukala. Njengamanje, ukuthuthukiswa nokusetshenziswa kwe-HMB emkhakheni wokudla kwasekhaya kusanda kuqala, kodwa ngokususwa kwezithiyo zokulawula zasekhaya, kanye nokukhuphuka nokukhuthazwa kokudla okuhlukahlukene kwe-HMB okusebenzayo emakethe yomhlaba wonke, kukholakala ukuthi esikhathini esizayo esiseduze, i-HMB izoba nethemba elibanzi lentuthuko emkhakheni wokusetshenziswa kokudla.