I-Vitamin B3, eyaziwa nangokuthi i-niacin, iyivithamini encibilikayo emanzini eyenza imisebenzi ehlukahlukene ebalulekile yomzimba. Ucwaningo lwangaphambili luye lwabonisa ukuthi i-vitamin B3 ibamba iqhaza ohlelweni lwe-metabolism yamandla omzimba, ikhuthaza umzimba wamangqamuzana esikhumba, futhi inomphumela othile we-antioxidant.

Isifo sesibindi esinamafutha e-non-alcoholic (NAFLD), yisona sigameko esiphezulu sohlobo lwesifo sesibindi esingamahlalakhona e-China, kuneziguli ezingaphezu kwezigidi ezingu-150 e-China, lapho i-10-20% yazo izoqhubeka ithuthuke ibe yi-non-alcoholic steatohepatitis (NASH), ebonakaliswa ngokuyinhloko ukuvuvukala nokulimala kwamangqamuzana esibindi, okuvame ukuhambisana ne-fibrosis. I-NASH ithuthuka ngokushesha futhi isengozini enkulu yokuthola izifo zesibindi ezinzima njenge-cirrhosis nomdlavuza wesibindi.

Muva nje, Abacwaningi abavela eSikoleni Sezempilo Yomphakathi e-Sun Yat-sen University bashicilele iphepha kumagazini i-JAMA Network Open enesihloko esithi "I-Dietary Niacin Intake and Mortality Among Individuals With Nonalcoholic. Isifo Sesibindi Esinamafutha "iphepha locwaningo.

Ucwaningo lubonise ukuthi ukwengezwa nge-vitamin B3, noma ukunciphisa ingozi yokufa konke ezigulini ezine-non-alcoholic fat fat disease, kuhlotshaniswa nokuncipha kwe-30% engozini yokufa kwembangela yonke kubahlanganyeli abanomthamo ophezulu kakhulu (≥26.7mg / ngosuku) uma kuqhathaniswa nabahlanganyeli abanosuku oluphansi kakhulu lwe-18.4 mg / ≤.

Kulolu cwaningo, abacwaningi bahlaziye ukuhlangana phakathi kokudla kwe-vitamin B3 yokudla kanye nengozi yokufa kweziguli ezine-non-alcoholic fat fat disease ngokuqoqa ukudla kwe-vitamin B3 etholakala ku-National Health and Nutrition Examination Survey (NHANES) i-database ye-4,315 NAFLD iziguli ezinesilinganiso seminyaka ye-53.

Abahlanganyeli bahlukaniswe ngamaqembu amathathu ngokusekelwe ekudlaleni kwe-vitamin B3: iqembu elincane lokuthatha (≤18.4mg / ngosuku), iqembu lokuthatha eliphakathi (18.5-26.6mg / ngosuku) kanye neqembu eliphezulu lokudla (≥26.7mg / ngosuku).
Phakathi nesikhathi sokulandelela esiyiminyaka eyi-8.8, inani lokufa kwe-566 labhalwa, i-197 yalo libangelwa isifo senhliziyo.

Ukuhlaziywa kutholwe ukuthi ababambiqhaza abadla kakhulu babenengozi ephansi ngamaphesenti angama-30 yokufa okuyimbangela yonke uma kuqhathaniswa nabahlanganyeli abathatha kancane kakhulu.

Ukwengeza, ababambiqhaza abathatha kakhulu babe nokuncipha ngamaphesenti angama-35 engcupheni yokufa kwenhliziyo nemithambo yegazi, kodwa lokhu bekungabalulekile ngokwezibalo.

Ukuhlaziywa okwengeziwe kwathola ukuxhumana okubalulekile phakathi kokuthathwa kwevithamini B3 kanye nobungozi besifo sikashukela kanye nokufa okuyimbangela, ngokuncipha okukhulu kokufa ezigulini ezingezona ezinesifo sikashukela uma kuqhathaniswa nalabo abanesifo sikashukela.

Ngokusho kwabacwaningi, i-niacin ingenye yezandulela ze-NAD synthesis futhi isibe inhloso ebalulekile yokuvimbela nokwelashwa kwesifo sesibindi. Ucwaningo lokungenelela kwabantu luye lwabonisa nokuthi i-niacin ingathuthukisa isibindi esinamafutha futhi inciphise okuqukethwe kwamafutha esibindi. Ezifundweni zangaphambi komtholampilo, i-niacin itholakale ivimbela futhi ihlehlise i-steatosis yesibindi nokuvuvukala, futhi ivimbele i-fibrosis. Le miphumela ifinyelelwa ngokunciphisa ukucindezeleka kwe-oxidative, ukuvimbela i-diacylglyceryl acyltransferase 2 kanye nomsebenzi we-NADPH oxidase, nezinye izindlela ezingenzeka.

Kuhle ukusho ukuthi ngoSepthemba 2023, Abacwaningi abavela eSikoleni Sezempilo Yomphakathi eNyuvesi yaseSun Yat-sen bashicilela iphepha ephephabhukwini I-Nutrients enesihloko esithi "Inhlangano Phakathi Kokudla Kwe-Niacin Intake kanye Nezifo Zesibindi Ezingenatshwala: I-NHANES 2003-2018 "iphepha locwaningo.

Ucwaningo lubonise ukuthi ukuxhaswa kwe-vitamin B3 kwakuhlotshaniswa nengozi ephansi yesifo sesibindi esinamafutha angenalo utshwala, nalabo abathatha i-niacin ephezulu kakhulu (≥29.2mg / ngosuku) abanengozi ephansi ye-31% yesifo sesibindi esinamafutha angenalo utshwala uma kuqhathaniswa nalabo abane-niacin ephansi kakhulu yokudla (≤16.3mg / ngosuku).

Ihlanganiswe ndawonye, ????imiphumela iphakamisa ukuthi ukuxhaswa kwe-vitamin B3 kuhlotshaniswa nengozi ephansi ye-non-alcoholic fat fat disease kanye nengozi encishisiwe yazo zonke izinkinga zokufa kweziguli ezine-non-alcoholic fat fat disease. Ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe umthamo ophelele wevithamini B3 ukuze kuncishiswe ingozi yokufa okubangelwa yizo zonke iziguli ezine-NAFLD.