Isifo sesibindi esidakayo (ALD), okuyisifo sesibindi esibangelwa ukuphuza kakhulu isikhathi eside, singesinye sezifo zesibindi ezivamile eShayina, okuhlanganisa isibindi esinamafutha otshwala, i-alcohol hepatitis, i-alcohol liver fibrosis kanye nesifo sokusha kwesibindi sotshwala. Eminyakeni yamuva nje, ukwanda kwezifo zesibindi sotshwala kubonise umkhuba okhulayo eChina.

Ngomhla zi-2 kuJulayi, 2024, uLiu Zhihua waseTsinghua University, u-Wang Hua wase-Anhui Medical University, u-Yin Shi we-University of Science and Technology yase-China kanye nabanye abacwaningi bashicilela i-athikili enesihloko esithi "I-Dietary fiber inciphisa ukulimala kwesibindi esidakayo ngokusebenzisa" kujenali ethi Cell Host & Microbe "Bacteroides acidifaciens and submacience".

Ukudla okunothe ngefayibha yokudla encibilikayo kwatholakala ukwandisa ukuchichima kwe-B. accidifaciens nokunciphisa ukulimala kwesibindi okubangelwa utshwala kumagundane.

Kumshini, i-B.accifaciens ilawula i-bile acid metabolism nge-bile saline hydrolysis enzyme (BSH). Ukwanda kwe-bile acid engabopheli kusebenze indlela ye-FXR-FGF15 emathunjini, ivikela umsebenzi wokuvinjelwa kwamathumbu emathunjini, ikhuthaza ukubonakaliswa kwe-ornithine aminotransferase (OAT) ku-hepatocytes, futhi ngaleyo ndlela ikhuthaze umzimba we-ornithine eqoqwe esibindini ukuze i-glutamate. Nikeza izinto ezingavuthiwe zokuqeda ubuthi besibindi futhi unciphise ukulimala kwamaseli esibindi.

lolu cwaningo, abacwaningi baqala ukubangela isifo sesibindi esidakayo kumodeli yegundane futhi bahlaziya imiphumela ye-fiber yokudla enesifo sesibindi esidakayo kumagundane ngokufaka kokubili i-fiber e-soluble ne-insoluble.

Imiphumela yathola ukuthi i-soluble dietary fiber supplementation yathuthukisa kakhulu isifo sesibindi esidakayo kumagundane, okuhlanganisa ukunciphisa i-steatosis yesibindi nokunciphisa iphesenti kanye nenani eliphelele lama-neutrophils esibindi, kuyilapho i-fiber yokudla engenakuqhathaniswa ayizange ibe nomphumela ophawulekayo.

Ngenxa yokuthi i-fiber yokudla ingathinta kakhulu i-gut microbiota, abacwaningi baphinde bahlaziya ukuthi ngabe ukuthuthukiswa kwesifo sesibindi esidakayo kungenxa ye-gut microbiota ngokusebenzisa amasu okufakelwa kwe-microbiota.

Ngemuva kokufakelwa kabusha, kwatholakala ukuthi ukufakelwa kabusha kwe-microflora yamagundane adla i-soluble dietary fiber kunciphisa i-serum alanine aminotransferase (ALT) kanye namazinga e-aspartate aminotransferase (AST), kuyilapho kunciphisa i-steatosis yesibindi kanye namazinga okuvuvukala, okusikisela ukuthi i-soluble dietary fiber ingase ibe nomthelela ekuthuthukiseni i-ALD ngokulungisa kabusha ukwakheka kwe-microflora yamathumbu.

Ucwaningo lubonise ukuthi i-soluble dietary fiber ithuthukisa i-necrosis yesibindi sesibindi, i-steatosis yesibindi nokuvuvukala kumodeli yegundane yesifo sesibindi sotshwala, futhi yanciphisa izinga le-ammonia yegazi kanye nokucindezeleka okwenziwe nge-oxidative, okugqamisa indima ebalulekile ye-soluble dietary fiber ekuvimbeleni nasekwelapheni isifo sesibindi esidakayo.

Kubalulekile ukuqaphela ukuthi abantu abadala ngokuvamile batuswa ukuba badle amagremu angu-25-30 noma ngaphezulu kwe-fiber yokudla ngosuku, kodwa abantu abaningi abahlangabezani nezincomo zokudla. Okusanhlamvu okuphelele, izithelo nemifino kuyimithombo ecebile ye-fibre yokudla futhi inganikeza amanye ama-micronutrients abalulekile.

Kafushane, imiphumela iphakamisa ukuthi ukudla okucebile ku-fiber yokudla e-soluble kungathuthukisa ukulimala kwesibindi okubangelwa utshwala kumamodeli wegundane kuyilapho kuvikela ubuqotho besithiyo samathumbu. Lolu cwaningo lunokubaluleka okuthile komtholampilo kanye nokubaluleka komphakathi.

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