I-Sucralose ayibambi iqhaza kumetabolism emzimbeni womuntu futhi ayimuncwa umzimba womuntu. Ngevelu ye-calorific engu-zero, i-sucralose iyindawo emnandi efanelekile yabanesifo sikashukela. Yacwaningwa futhi yaqinisekiswa yi-FDA ngo-1998. Ingasetshenziswa njenge-sweetener yendawo yonke yakho konke ukudla, futhi ayithinti ukugcwala kweglucose egazini. Ingamukelwa iziguli ezinesifo sikashukela. Ngaphezu kwalokho, i-sucralose ayisetshenziswa amagciwane e-caries yamazinyo futhi inganciphisa inani le-asidi ekhiqizwa amagciwane omlomo kanye nokunamathela kwamaseli e-streptococcal ebusweni bamazinyo, idlale ngempumelelo indima ye-anti caries. Ucwaningo lwezilwane lubonise ukuthi i-sucralose iphephile ukuthi isetshenziswe isikhathi eside ngemithamo ephakeme izikhathi ezingamakhulu ambalwa kunamazinga okusetshenziswa komuntu. Ukuhlolwa kwesikhathi eside okwenziwa kumavolontiya abantu ajwayelekile kukhombisile ukuthi i-sucralose ayinayo imiphumela engabuyiseleki empilweni yomuntu. Ngemuva kokuhlolwa kwesitifiketi sokuphepha sesikhathi eside, i-US FDA isiqinisekisile ukuthi iyisengezo sebanga le-GRAS (lezokuphepha).

I-Sucralose isetshenziswe kabanzi ezinhlotsheni zokudla ezingaphezu kuka-400, okuhlanganisa iziphuzo ezine-carbonated, iziphuzo ze-carbonated, iziphuzo ezidakayo, izithelo nemifino esemathinini, ukudla okufakwe emanzini anosawoti namasoso, ojamu, izinto ezibhakwayo, u-ayisikhilimu, imikhiqizo yobisi, okusanhlamvu kwasekuseni, kanye noshukela nsuku zonke. Iziphuzo ezinamakhalori aphansi ziyimakethe enkulu kunazo zonke yezishukela zokwenziwa, ezinabathengi abayizigidi ezingama-87 e-United States kuphela. I-Coca Cola kanye ne-PepsiCo bethule iziphuzo ezinekhalori ephansi ngokulandelana kwazo besebenzisa i-sucralose njengesiphuzo esimnandi, okuzoba okugxilwe kukho ekuthuthukisweni kwezimakethe esikhathini esizayo. Lokhu ngokungangabazeki kuzokwandisa kakhulu isidingo se-sucralose emakethe.