Ngasekuqaleni kwawo-1930, ososayensi bathola ukuthi ukuchayeka elangeni noma ukusetshenziswa kwamafutha omnqumo, uwoyela we-flaxseed, nokunye ukudla okufakwe imisebe ye-UV kungalwa ne-osteoporosis. Olunye ucwaningo olwenziwa ososayensi bahlonze futhi baqamba uvithamini D njengesithako esisebenzayo emzimbeni womuntu sokulwa ne-osteoporosis.

I-Vitamin D (i-VD ngamafuphi) iyivithamini encibilikayo enamafutha, okuyiqembu lezinto eziphuma kuma-steroid ezinemiphumela yokulwa nama-rickets kanye nezakhiwo ezifanayo. Okubaluleke kakhulu uvithamini D3 (cholecalciferol, cholecalciferol) novithamini D2 (calciferol). I-Vitamin D ekudleni ngokuyinhloko ivela ekudleni okusekelwe ezilwaneni njengesibindi senhlanzi, isikhuphasha seqanda, ibhotela, njll. Ngemva kokungenisa, idonswa emathunjini amancane phambi kwe-bile futhi ihanjiswe egazini ngendlela yama-chylomicrons. Iguqulwa ibe yi-1,25-dihydroxyvitamin D3 ngesibindi, izinso, ne-mitochondrial hydroxylase, enomsebenzi wezinto eziphilayo futhi ingashukumisa ukuhlanganiswa kweprotheni ebopha i-calcium (CaBP) ku-mucosa yamathumbu, ikhuthaze ukumuncwa kwe-calcium, futhi ikhuthaze ukubala kwamathambo. I-7-dehydrocholesterol, i-cholesterol ephuma emzimbeni womuntu, igcinwa ngaphansi kwesikhumba futhi ingaguqulwa ibe yi-cholecalciferol ngaphansi kokukhanya kwelanga noma imisebe ye-ultraviolet. Kuyivithamini D engapheli ekhuthaza ukumuncwa kwe-calcium ne-phosphorus.

I-VD iphuma kuma-steroid. I-crystal emhlophe, e-soluble emafutheni, enezakhiwo ezizinzile, ukumelana nokushisa okuphezulu, i-antioxidant, engamelani ne-asidi ne-alkali, futhi ingabhujiswa ukubola kwe-fatty acid. Isibindi sezilwane, amafutha esibindi senhlanzi, nesikhupha seqanda kunothile ngokuqukethwe. Imfuneko yansuku zonke yezinsana, izingane, intsha, abesifazane abakhulelwe, nomama abancelisayo ngama-400 IU (amayunithi ngamazwe ngamazwe). Uma ingekho, abantu abadala bathambekele ekubeni ne-osteomalacia, futhi izingane zivame ukuba nama-rickets. Uma i-calcium yegazi iyancipha, kungase kube nokunyakaziswa kwezandla nezinyawo, ukuxubha, njll, okuhlobene nokuthuthukiswa kwamazinyo. Ukudla kakhulu uvithamini D kungabangela i-calcium eningi egazini, ukulahlekelwa ukudla, ukuhlanza, isifo sohudo, ngisho ne-ectopic ossification yezicubu ezithambile.