Umdlavuza wendlala yesinye (i-PC), ongomunye wemidlavuza evame kakhulu emadodeni, ufana nombulali othule, iningi leziguli zithola izimpawu ezikhula kancane zalesi sifo ezingagcina zikhule zibe umdlavuza osongela ukuphila. Ngaleso sikhathi, umdlavuza wendlala yesinye ungaba nzima kangangokuthi zonke izindlela zokwelapha ezitholakalayo aziphenduli kuwo.

Njengoba isisho sisho, ukwelashwa kuncike "kumaphuzu amathathu emithi, amaphuzu ayisikhombisa okugcinwa", lokhu "ukugcinwa" isikhathi esiningi kubhekisela ku-tonic yokudla. Umdlavuza wendlala yesinye yisifo esiqhubeka isikhathi eside. Uma izindlela zokungenelela ezifanele, ezifana nendlela yokuphila enengqondo nokudla, zingamukelwa ekuqaleni kwesifo, kungase kubambezeleke ngokuphumelelayo ukuqhubeka komdlavuza wendlala yesinye futhi kuthuthukise ukubikezelwa kweziguli.

Ngomhla zingama-25 kuMfumfu, 2024, ithimba likaSolwazi Lloyd Trotman we-Cold Spring Harbour Laboratory lanyathelisa kujenali yezemfundo ephakeme yamazwe ngamazwe i-Science enesihloko esithi: Ukwelashwa kwe-pro-oxidant ye-Dietary pro-oxidant precursor ka-vitamin K kuqondise iphepha lokucwaninga le-PI 3-kinase VPS34.

Ucwaningo luthole ukuthi i-pro-oxidant supplement, i-menadione (uvithamini K3), ingabambezela ukuqhubeka komdlavuza wendlala yesinye. I-Menadione iyisandulela sikavithamini K ongancibilika emanzini, ovame ukutholakala emifino enamahlamvu aluhlaza, futhi umsebenzi wayo wokuphila komzimba ungowokukhuthaza ukujiya kwegazi nokubamba iqhaza ekuhlanganiseni amathambo.

Ucwaningo lwe-Mechanism lubonise ukuthi i-VPS34 iyinhloso eyinhloko ye-phosphatidylinositol 3-kinase (PI3K), i-menadione ingavimbela umsebenzi we-VPS34, inciphise ukukhiqizwa kwe-PI3P, futhi ikhulise ukucindezeleka okwenziwe nge-oxidative okuholela ekufeni kwamangqamuzana omdlavuza we-prostate. Ngokuphambene, amangqamuzana avamile akhula kancane futhi ngenxa yalokho abe nemithombo yamandla eyanele ukuze amelane nalo monakalo. Ngaphezu kwalokho, ithimba locwaningo libonise ukuthi i-menadione iphinde ibe nomthelela wokwelapha esimweni esibulalayo sofuzo esibizwa ngokuthi i-X-linked myotubulin myopathy (XLMTM).

Lokhu okutholakele kuveza indlela elula kodwa ephumelelayo yokungenelela emdlavuza futhi ibe nemiphumela emisha yokwelashwa kwezinye izifo zofuzo ezibangelwa ukungasebenzi kahle komsebenzi we-kinase.

Ithimba liphathe amamodeli egundane le-RapidCaP ngesithasiselo se-pro-oxidant, i-menadione sodium sulfite (MSB), inhlanganisela engumanduleli wezilwane ezincelisayo ku-vitamin K. Bathola ukuthi isengezo sansuku zonke se-MSB emanzini okuphuza singavimbela ukuqhubeka komdlavuza wendlala yesinye futhi sikhiqize umphumela ongapheli wokuvimbela.

Sekukonke, ucwaningo, olushicilelwe kuSayensi, luphakamisa ukuthi ukwengeza izithasiselo ze-pro-oxidant ekudleni ukuze kwengeze i-MSB kungabambezela ngempumelelo ukuqhubeka kwesifo somdlavuza wendlala yesinye. Lokhu kungenxa yokuthi i-MSB ingavimbela umsebenzi we-PI3K kinase VPS34, inciphise ukukhiqizwa kwe-PI3P, futhi ikhulise ukucindezeleka kwe-oxidative, okuholela ekufeni kwamangqamuzana omdlavuza wendlala yesinye. Ukwengeza, ku-X-linked myotubular myopathy (XLMTM), i-MSB ingavimbela umsebenzi we-kinase we-VPS34, ukubuyisela i-PI3P kumazinga angathuthukisa ukuthuthukiswa kwemisipha.