0102030405
Kungani i-mannitol isebenza ezifweni ze-urinary tract
2025-03-13
- I-Mannose (noma i-D-Mannose) ingushukela olula, kodwa ngokungafani ne-glucose, i-mannose ayimuncwa kalula umzimba ngemva kokusetshenziswa, futhi u-90% wemannose ukhishwa ngokuqondile ngomchamo ngemva kwemizuzu engaba ngu-30 kuya kwengama-60 ngemva kokuwuthatha, ngakho ngokungafani ne-glucose, i-mannose ayiwuthinti ushukela wegazi, kodwa igxile kakhulu emchamweni. Imannose ingaphazamisa i-glucose metabolism, ivimbele ukufakwa kwamafutha, ilawule izitshalo zamathumbu futhi ibambe iqhaza ekulawuleni amasosha omzimba. Ukuqonda okuphelele kwendlela yokusebenza kwe-mannose ekwelapheni izifo ezihlobene kuyisihluthulelo sokwandisa ukusetshenziswa kwayo emtholampilo.Eminyakeni yamuva, kuye kwaba nezifundo eziningi nge-mannose. Namuhla, sizoxoxa ngokuthi i-mannose ayinawo yini umthelela ekwelapheni ukutheleleka komgudu womchamo. Ukutheleleka komgudu womchamo yisifo esibangelwa ukutheleleka ngebhaktheriya kunoma yisiphi izicubu zesitho esisemgwaqweni womchamo, okuhlanganisa izinso, ureter, esinyeni, urethra, njll., kodwa ukutheleleka komgudu womchamo kuvame ukubuswa esinyeni kanye ne-urethra. Ngenxa yomehluko ongokomzimba phakathi kwabesilisa nabesifazane, abesifazane banethuba eliphezulu lokutheleleka ngomchamo kunabesilisa. Ucwaningo lubonisa ukuthi abesifazane banamathuba angamaphesenti angu-50 okuba nesifo somzila womchamo ngesikhathi sokuphila kwabo, kanti phakathi kwengxenye yesithathu nengxenye yalabo abanaleli gciwane bazongenwa igciwane ungakapheli unyaka.Kusukela ngawo-1980, i-mannose ibisetshenziswa odokotela bemithi esebenzayo ukwelapha izifo zomgudu womchamo. Eminyakeni yamuva nje, ngobufakazi obuningi bocwaningo obufakazela imiphumela yokwelapha neyokuvimbela ye-mannose, indima ye-mannose ekwelapheni ukutheleleka komgudu womchamo kancane kancane idonse ukunaka kwemithi evamile.
Isebenza kanjani i-mannose?Lapho ikhishwa ngezinso, esinyeni, kanye ne-urethra, i-mannose izovala amangqamuzana ezicubu ezidlulayo kanye namagciwane azama ukunamathela kumaseli, okwenza amagciwane angakwazi ukunamathela esinyeni kanye namaseli omzila womchamo, avimbe indlela yokutheleleka ngamagciwane, futhi amagciwane angakwazi ukunamathela ezicutshini zomgudu womchamo azolandela umchamo ngaphandle komchamo. Izifo eziningi zomgudu womchamo zibangelwa uropathogenic Escherichia coli (UPEC). I-UPEC ibophezela kumannose ngaphezulu kwamaseli e-epithelial sesinye ngephrotheni ye-FimH futhi ayigezwa kalula umchamo. Balungise i-mannose ukuze bathole i-mannoside (M4284). Ukuhlobana kwayo neprotheni ye-FimH iphakeme ngokuphindwe izikhathi ezingu-100,000 kune-mannose, kodwa ayinamatheli ngaphezu kwesinye futhi ingakhishwa nge-E. coli emchamweni.Ocwaningweni lwamazwe ngamazwe lwango-2016, iziguli ezithathe i-mannose izinsuku ezingu-13 zithole ukuncipha okukhulu kwezimpawu kanye nokuthuthuka okuphawulekayo kwezinga lempilo yazo njengoba kuhlolwa imibuzo. Ukuze uvimbele ukutheleleka okuphindaphindiwe kwe-urinary tract, abacwaningi bahlukanisa iziguli ngamaqembu amabili, iqembu lokungenelela laqhubeka nokuthatha i-mannose, iqembu lokulawula alinalutho. Umphumela weqembu le-mannose, amaphesenti angu-4.5 kuphela okuphindaphinda phakathi nezinyanga eziyisithupha, uma kuqhathaniswa namaphesenti angu-33.3 weqembu lokulawula. Abacwaningi baphethe ngokuthi i-mannose ingasiza ekwelapheni izifo eziyingozi zomchamo futhi ingavimbela ngempumelelo ukuphindeka kwezifo ze-urinary tract.