I-yeast beta-glucan iyi-polysaccharide esebenzayo etholakala odongeni lweseli ye-yeast. Ngo-1941, uDkt. Pillemer wathola into ethile odongeni lwe-yeast cell ekhulisa ukuzivikela komzimba. Ngo-1961 u-Riggi wakhomba lesi sithako esisebenzayo ku-yeast glycan njenge-beta-glucan [1]. Imithombo evamile ye-beta-glucan futhi ihlanganisa i-oats, isikhunta, izimila zasolwandle, njll., ngoba umzimba awukwazi ukuhlanganisa noma ukukhiqiza i-beta-glucan ngokwayo, kufanele yengezwe yizwe langaphandle.

Ngaphezu kwe-β-glucan ne-yeast cell wall, kukhona ne-mannose encibilika emanzini kanye nenani elincane le-chitin, i-β-glucan ibalwa ku-30% kuya ku-60% wesisindo esomile sodonga lwamaseli, ongqimbeni olungaphakathi kakhulu lodonga lwamaseli, luyingxenye ye-polysaccharide yesakhiwo, umsebenzi oyinhloko we-physiological ukugcina ukuqina kwengqamuzana, ukugcina iseli ye-mechanical. UMisaki et al. ithole ukuthi ukwakheka kweyeast β-glucan ngokuyinhloko yakhiwe yi-β-1, 3-bond, futhi iqukethe ingxenye ethile yezinsalela ze-β-1, 6-bond.

Ukusebenza kwe-immunomodulatory ye-yeast beta-glucan kuncike ekuqondisweni kwayo okunembile, amandla ayo okubopha kuma-receptors athile ebusweni bamasosha omzimba, kuyilapho kuthuthukisa umsebenzi we-phagocytosis wama-macrophages. Le nqubo ikhulisa ngokushesha ukusabela komzimba komzimba futhi igcine ibhalansi efanele yamasosha omzimba.

I-Beta-glucan yenza ngokuyinhloko ngokubophezela ezinhlotsheni ezintathu ze-beta-glucan receptor [4]: ??(1) i-Dectin-1 receptor; (2) CR3; (3) Amanye ama-receptors, kuhlanganise ne-scavenger receptor kanye ne-LacCer. Uma imvubelo i-β-glucan ingena emzimbeni womuntu futhi ibophezela ku-receptor, izokwandisa i-phosphorylation ye-intracellular immune receptor tyrosine motif (ITAM) ne-Syk, futhi isebenze indlela ye-PI3K / Akt, ekugcineni eholela ku-phagocytosis, ukufa kwe-microbial kanye nokukhululwa kwe-cytokine, ukuze kuvinjwe kangcono ukukhishwa kwegciwane kwamanye amazwe. Bese uthola umphumela wokugomela.

Izinzuzo zezempilo zesikhumba ze-beta-glucan zibonakala ngokuyinhloko kulezi zici ezilandelayo [6]:

I-1) Umthamo we-Antioxidant: I-β-glucan inezakhiwo ze-antioxidant, ezingavimbela ukukhiqizwa kwe-superoxides nezinye izinhlobo ze-oksijeni ezisebenzayo (ROS) futhi zinciphise umonakalo wokucindezeleka okwenziwe nge-oxidative esikhumbeni.

I-2) Umphumela wokuswakama: Ngesisindo sayo samangqamuzana aphezulu, i-β-glucan inekhono eliqinile lokubopha amanzi, elinganamathisela ngempumelelo ama-molecule amanzi ebusweni bamangqamuzana esikhumba, livimbele ukuhwamuka kwamanzi, futhi linciphise ukulahlekelwa kwamanzi nge-epidermis (TEWL). Ngaphezu kwalokho, yakha ifilimu yokuzivikela ebusweni besikhumba, isiza ukugcina umswakama nokuthambile esikhumbeni.

3) Ukulungiswa kwesikhumba kanye namandla okuphulukisa: Seo et al. ithole ukuthi imithombo ehlukene ye-beta-glucan ingakhuthaza ukufuduka kwama-keratinocyte abantu (HaCaT) kanye ne-fibroblasts yesikhumba somuntu (i-HDFa), futhi isheshise ukuvalwa kwesilonda kanye nokuphinda kufakwe i-epithelialization kumamodeli wamagundane [7]. Ngaphezu kwalokho, izakhiwo ezilwa nokuvuvukala nezilwa nokucasuka ze-beta-glucan zisiza ukukhulula ukuvuvukala nokubabomvu futhi zidambise isikhumba esicasuliwe. Ucwaningo ku-Journal of Therapeutic Dermatology lubonise ukuthi i-beta-glucan iyisengezo esisebenzayo ekwelapheni i-atopic dermatitis emnene (i-eczema) [8].

I-4) Imiphumela yokuguga: I-Beta-glucan isiza ukunciphisa izimpawu zokuguga kwesikhumba, njengemibimbi nokuwohloka. Ikhuthaza ukuhlanganiswa kwe-collagen nezinye izingxenye ze-extracellular matrix (ECM) zesikhumba, okwandisa ukushuba nokunwebeka kwesikhumba.

Ngaphezu kwalokho, i-beta-glucan nayo inendima yokulawula izitshalo zamathumbu, ukunciphisa i-cholesterol, ukulwa nokukhathala, impilo yamathambo nokunye.

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