Emkhakheni wocwaningo lwezempilo emathunjini, i-Polydextrose sekuyisikhathi eside ihlukaniswa njengefayibha yokudla evamile encibilika emanzini. Kodwa-ke, ucwaningo oluthile oluyimpumelelo eminyakeni yamuva lubonise ukuthi le molekyuli yokwenziwa eyenziwe i-polymerized kusuka ku-glucose empeleni "isidlali esishintshashintshayo" esilungisa kabusha i-microecology yamathumbu ngokusebenzisa indlela emithathu "yokulawulwa kwe-viscosity eguqukayo - ukuphakelwa okunembile kwe-microbiota - metabolite cascade reaction". Ucwaningo lwakamuva ku-Nature Gastroenterology ngo-2024 lubonisa ukuthi ukudla kwansuku zonke kwe-10-15g ye-polyglucose kungakhuphula ubuqotho besithiyo samathumbu ngo-37% futhi kwehlise izinga lesici sokuvuvukala IL-6 ngama-29%. Lokhu kutholwa akugcini nje ngokuchitha ukuqonda okungokwesiko kodwa futhi kubangela igagasi lokusebenzisa izigwegwe ezihlukahlukene kusukela embonini yokudla kuye kwezokwelapha.

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I-Youdaoplaceholder0 ISahluko 1 Sokuqopha Isayensi: "Ubuhlakani bepheshana lokugaya lonke" le-molecule

I-Youdaoplaceholder0 1.1 I-Viscosity deformation: "Ukusabela okuhlakaniphile" kusuka esiswini kuya kukholoni

Ukuhluka kwe-polydextrose kusekushintsheni kwayo kwe-viscosity esabela nge-P:

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I-Youdaoplaceholder0 Isisu (pH 1.5-3.0) : Amaketango e-molecular axhunywe ngokuphambana ngamabhondi e-hydrogen ukuze akhe uhlaka lwenethiwekhi olunezinhlangothi ezintathu, insipho ye-viscosity efika ku-1500 mPa·s, yehlisa izinga lokuphuma kwesisu ngokufika ku-45% (uma kuqhathaniswa ne-enhanciary fibre) evamile kakhulu

I-Youdaoplaceholder0 Ithumbu elincane ? (pH 6.0-7.4) : Amabhondi e-hydrogen aphulwa kancane, i-viscosity yehliswa ibe ngu-400 mPa·s, futhi ukumuncwa kwe-bile acid kunciphisa ukumuncwa kwe-cholesterol ngo-18% ngaphandle kokuphazamisa ukumuncwa kwezakhi;

I-Youdaoplaceholder0 Colon ? (pH 7.0-7.5) : Ukuvutshelwa kwe-Microbial kuyaqalwa, i-viscosity ihlakazeka ibe ngaphansi kuka-50 mPa·s, ama-short-chain fatty acids (ama-SCFAs) ayakhululwa, kanti ukugxiliswa kwe-butyric acid kukhuphuka izikhathi ezingu-3.2, kuvule ngokuqondile i-epitheal cell ye-intestinal1.

I-Youdaoplaceholder0 Technology Breakthrough : Ubuchwepheshe be-SmartVisc? be-DSM bungenza ngendlela oyifisayo amajika e-viscosity kumasegimenti ahlukene ngokulawula izinga le-polymerization (inani le-DP), njengefomula yohlobo lwe-G eklanyelwe ngokukhethekile iziguli ezine-reflux ye-gastroesophageal, eyenza ifilimu evikelayo ephathekayo ene-viscosity efika ku-2000 mPa·000 esiswini.

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I-Youdaoplaceholder0 1.2 Umthetho we-Microbiota: Ukusuka "ekuphakeleni okubanzi kwe-spectrum" kuya "kukuzuza okuhlosiwe"

Ama-prebiotics endabuko avame ukuvuselela yonke i-microbiota ngokungakhethi, kuyilapho i-polydextrose ibonisa amandla okulawula anembile:

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I-Youdaoplaceholder0 I-Upstream inhibition : Isimo se-viscosity esiphezulu sakha umgoqo ongokoqobo ku-proximal colon, okuvimbela ukunamathela kwamabhaktheriya e-pathogenic (afana ne-Escherichia coli), ehlisa izinga le-pathogen colonization ngo-52%;

Ukwanda komfula i-Youdaoplaceholder0 : Izingcezu ze-oligosaccharide zazisetshenziswa ngokukhethekile amagciwane anenzuzo afana ne-Bifidobacterium ne-Roseella, futhi ubuningi bazo bukhuphuke ngo-68% ngemva kwamasonto angu-8 okungenelela (ngokusekelwe ekulandeleni kwe-metagenomic);

I-Youdaoplaceholder0 I-Metabolic synergy : I-Butyric acid ekhiqiziwe yenza kusebenze isamukeli se-GPR109A, ingenisa ukuhlukaniswa kwamaseli e-T alawulayo, futhi ithuthukise inkomba yebhalansi yokuzivikela emathunjini ibe ngu-0.91 (umkhawulo wezempilo > 0.85).

I-Youdaoplaceholder0 Isahluko 2 Sokucela Isiphepho: Ukuzijwayeza Ukuwela Umngcele ukusuka Etafuleni ukuya Embhedeni Wesibhedlela

I-Youdaoplaceholder0 2.1 Imboni Yokudla: "Injini engabonakali" enezici ezithuthukisiwe

I-Youdaoplaceholder0 Baking Revolution ? : Iqembu le-Meiji lase-Japan lenze amakhukhi ayi-zero-sucrose ngokusebenzisa amandla okubamba amanzi (8.3g amanzi /g) kanye nokuzinza okushisayo (ukubekezelela kufika ku-220 ° C) kwe-polyglucose, ukwehlisa ukushintshashintsha kweglucose yegazi ngemva kokudla ngo-41%.

I-Youdaoplaceholder0 Beverage Innovation : I-Nongfu Spring's Intestinal Sparkling Water, esebenzisa indawo ekhiqiza igesi ebilayo ye-polyglucose ukuze iqede ukuqunjelwa ngaphandle kokucasuka, idayiswe amabhodlela angaphezu kwezigidi ezingu-8 ngenyanga yayo yokuqala emakethe;

Impumelelo ye-Youdaoplaceholder0 Meal Replacement : I-Soylent e-US isebenzisa ifomula ye-viscosity-gradient ukuze inwebe isikhathi sokukhipha amandla kancane sibe amahora angu-6 futhi ithuthukise ukukhuthazela kwabagijimi bemarathon ngo-23%.

I-Youdaoplaceholder0 2.2 Ukudla okunempilo komtholampilo: "Isivikelo sokuvimbela amathumbu" ezigulini zase-ICU

Ucwaningo lwe-RCT lweSibhedlela i-Sir Run Run Shaw, Isikole Sezokwelapha, Inyuvesi yaseZhejiang (n=204) lubonisa ukuthi:

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I-Youdaoplaceholder0 Ukuvimbela Ukutheleleka : Ezigulini ze-ICU ezingezwe ngo-15g we-polydextrose nsuku zonke, izehlakalo ze-enterogenous sepsis zehle ngo-44%;

I-Youdaoplaceholder0 Ukulungiswa kwe-mucosal ? : Amazinga e-Plasma ligonin (umaka wokukwazi ukungena emathunjini) ehle ngo-31% kanti ukuminyana kwamaseli e-goblet kukhuphuke ngo-39%;

I-Youdaoplaceholder0 Immunomodulatory ? : Ukugxiliswa kwe-Serum IgA kukhuphuke ngo-28%, futhi isilinganiso samaseli e-CD4+/CD8+ T sibuyele ebangeni elivamile.

I-Youdaoplaceholder0 Isahluko 3 Uguquko Lwezobuchwepheshe: Ukusuka Kumklamo Wemolekyuli kuya Kukudla Okunembayo Okunikwe amandla yi-AI

I-Youdaoplaceholder0 3.1 Ukulungiswa Kwesakhiwo: Vula Ukwenza ngokwezifiso uma kudingeka

I-Youdaoplaceholder0 I-viscosity eqondisiwe : Ngokwethula amaketango aseceleni e-sorbitol, i-polyglucose ehlakazekayo egxile kukholoni (uhlobo C) yathuthukiswa, okubukeka kwayo kwehle kakhulu kwaya ku-10 mPa·s ku-pH 7.0, ikakhulukazi abantu abanokuqunjelwa;

Usikompilo oluthuthukisiwe lwe-Youdaoplaceholder0 : I-Roguet, e-France, ithuthukise ubuchwepheshe be-Probiocoat? microcapsule obuhlanganisa ama-probiotics ku-polyglucose matrix, okwandisa izinga lokusinda kwe-gastric acid kusuka ku-15% kuya ku-92%.

I-Youdaoplaceholder0 3.2 UBUCHWEPHESHE Okufakelwayo: Ukweqa Ikhodi Yokungenelela Okuqondene Nakho

Uhlelo lwe-"Digital Twin of the Intestine" olwakhiwe yi-NutriAI, inkampani yakwa-Israel, luhlanganisa amacala angu-200,000 edatha yezitshalo zamathumbu omuntu namamodeli we-fluid dynamics, engabikezela impendulo yomuntu ku-polydextrose:

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Ukulungiselela Umthamo we-Youdaoplaceholder0 : I-8-12g/ngosuku + yohlobo lwenhlanganisela ye-fructooligosaccharide enconyelwe iziguli ze-IBS yehlise izehlakalo zokuphazamiseka kwesisu ngo-67%;

I-Youdaoplaceholder0 Scene fit ? : Ifomula yokuzivocavoca ephezulu eklanyelwe abasubathi, enyusa izinga lokuvutshelwa kwamakholoni ngo-40% futhi igwema ukungaphatheki kahle kwesisu phakathi nokuqeqeshwa.

I-Youdaoplaceholder0 \ n \ nIsahluko Sesine: Izinxushunxushu Zezimboni: Impi Ephansi Yobuchwepheshe Ezimakethe Zezigidi Eziyizigidi

I-Youdaoplaceholder0 4.1 Umjaho Wamandla: Izinkampani zaseShayina zidlula ijika

I-Youdaoplaceholder0 I-Baolingbao Bio : Tshala izigidi ezingu-800 zamayuan ukuze kwakhiwe isizinda sokukhiqiza se-polyglucose esikhulu kunazo zonke emhlabeni, ubuchwepheshe be-enzymatic synthesis ukuze kuzuzwe ubumsulwa obungu-99.9%;

I-Youdaoplaceholder0 I-Hualixi Biotech : I-nano-fibrotic polyglucose ethuthukisiwe, ukuzwela kwe-viscosity regulation kukhuphuke izikhathi ezi-4, kutholwe imvume yokudla okukhethekile kwe-NMPA yezokwelapha;

Isakhiwo se-Youdaoplaceholder0 Transnational : I-DuPont isebenzisana neMayo Clinic ukuthuthukisa uhlolo lomtholampilo lweSigaba III se-polydextrose ekuvimbeleni umdlavuza we-colorectal.

I-Youdaoplaceholder0 4.2 Izinselele Zokuqonda: Igebe elisuka eLebhu ukuya eMass Market

Naphezu kobufakazi obanele besayensi, ucwaningo lwabathengi lubonisa ukuthi:

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I-Youdaoplaceholder0 Indawo eyimpumputhe yoLwazi : Kuphela ama-31% omphakathi aqonda umehluko wokusebenza phakathi kwe-polydextrose nemicu evamile;

Imithamo eyiphutha ye-Youdaoplaceholder0 : Amaphesenti angu-45 wabathengi akholelwa ngephutha ukuthi "okuningi kungcono", okungase kubangele ukungakhululeki njengokuqunjelwa;

Impendulo Yemboni ye-Youdaoplaceholder0 : I-Chinese Nutrition Society ikhiphe I-White Paper mayelana nokusetshenziswa kwe-Polydextrose, ibeka umkhawulo ophephile ongu-15g ngosuku.

I-Youdaoplaceholder0 Isahluko 5 Umbono Wekusasa: Ukuchaza Kabusha 'I-Smart Boundary' ye-Fibre

I-Youdaoplaceholder0 5.1 Ukuphumelela kwe-Brain-Gut Axis: Ibhuloho Lemolekyuli ukusuka emathunjini ukuya ku-Emotion

Ukuhlolwa kwezilwane kwakamuva e-California Institute of Technology kutholile:

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I-Youdaoplaceholder0 Ukukhululeka kokukhathazeka : Amagundane eqenjini le-polyglucose intervention andise isikhathi sawo sokuhlola ekuhlolweni kwe-maze ngo-53%;

I-Youdaoplaceholder0 Indlela yokulandela umkhondo : I-Butyric acid yenza kusebenze isisho se-BDNF ku-hippocampus ngokusebenzisa umgoqo wegazi nobuchopho, inyusa ukuminyana kwe-synaptic ngo-29%.

Youdaoplaceholder0 5.2 Synthetic Biology: 'Ifomu Lokugcina' lemicu ehleliwe

Inkampani ye-Ginkgo Bioworks e-United States iguqule izinhlobo zemvubelo isebenzisa ubuchwepheshe be-CRISPR-Cas9 ukuze ikhiphe ngokuqondile "i-polydextrose efakwe ngofuzo" ngemisebenzi eyenziwe ngokwezifiso:

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Ukuqondisa okuqondile kwe-Youdaoplaceholder0 : Kungakhuthaza ngokukhethekile ukukhula kwe-Achaemenia, futhi ukuchichima kwayo kukhuphuka ngo-80% kumamodeli wokukhuluphala;

Impendulo ehlakaniphile ye-Youdaoplaceholder0 : Inzwa ye-pH eyakhelwe ngaphakathi, ukunemba koshintsho lwe-viscosity kuthuthukiswe ukuze kube ku-±5 mPa·s, okulindeleke ukuthi kungene ezivivinyweni zomtholampilo ngo-2026.

I-Youdaoplaceholder0 Isiphetho: Lapho i-molecular Intelligence ihlangana ne-Gut Ecology

Uhambo lwesayensi lwe-polydextrose umlando wokubuya kusuka "kumkhiqizo wezimboni" kuya "kunjiniyela wezinto eziphilayo zamathumbu". Lisitshela ukuthi impumelelo yeqiniso kwezempilo ivamise ukuvela ekwakhiweni okujulile kanye nokuhlelwa kabusha kwemingcele yengqikithi yendaba. Njengoba nje owathola umklomelo kaNobel uJennifer Doudna asho, "I-Synthetic biology isifundisa ukuthi ama-molecule anganikezwa 'ikhono lokucabanga'." Kule nguquko yezobuchwepheshe yempilo yamathumbu, i-polydextrose ingase ibe indawo yokuqala - lapho "ama-molecule ahlakaniphile" amaningi ejoyina impi, isintu ekugcineni sizofinyelela izinyathelo eziqondile zokulwa nezifo ezingapheli.